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Signaling Pathways

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  • AG-490 | 133550-30-8 | Structure | Supplier
    $50.00
    AG-490 (133550-30-8) is a potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently blocked cell growth, induced apoptosis and...

  • AICAR | 2627-69-2 | Structure | Supplier
    $45.00
    AICAR (2627-69-2) activates AMP-activated protein kinase (AMPK). Promotes ligand-independent activation of the insulin receptor. Promotes skeletal muscle autophagy via activation of FoxO3a. AICAR controls smooth muscle cell...

  • Anisomycin | Anoikis sensitizer
    $35.00
    Anisomycin (22862-76-6) activates JNK/SAPKs and reduces c-fos and c-jun. Protein synthesis inhibitor. Anisomycin induces apoptosis and sensitizes cells to anoikis. Cell permeable. References/Citations1) Hazzalin et al...

  • CUR 61414 | 334998-26-6 | Structure | Supplier
    $90.00
    CUR 61414 (334998-26-6) is a novel Hedgehog signaling pathway inhibitor (IC50=100-200 nM). Selectively binds to Smo but not other GPCRs. CUR 61414 blocks the formation of and induces the regression of basaloid lesions in...

  • Cyclopamine | 4449-51-8 | Structure | supplier
    $45.00
    Cyclopamine (4449-51-8) is a naturally occurring steroidal alkaloid with teratogenic activity. Blocks sonic hedgehog signaling by binding to smoothened. Antitumor activity. Cell Permeable. References/Citations1) Watkins et...

  • Cytochalasin D | Disrupts actin filaments
    $63.00
    Cytochalasin D (22144-77-0) is a potent inhibitor of actin polymerization which also causes the disruption of actin filaments. More potent that cytochalasin B (10-fold) and does not inhibit monosaccharide transport across...

  • DAPT | gamma-secretase inhibitor
    $60.00
    DAPT (208255-80-5)is an inhibitor of γ-secretase (IC50 in human primary neurons = 115 nM for total Aβ or 200 nM for Aβ42 specifically)1. Oral administration of DAPT has been shown to reduce levels of Aβ...

  • Deguelin | Akt inhibitor
    $70.00
    Deguelin (522-17-8) inhibits Akt.1,2 Induces apoptosis in a variety of cells.2,3 Displays cancer chemopreventive activity.4 Deguelin is cell permeable and active in vivo. References/Citations1) Chun et al...

  • Enzastaurin | PKC inhibitor
    $45.00
    Enzastaurin (170364-57-5) is a potent and selective PKCβ inhibitor.  IC50 = 6, 39, 83 and 110 nM, for PKCβ, PKCα, PKCγ and PKCε respectively.1 Induces apoptosis in multiple myeloma cell...

  • Everolimus | mTOR inhibitor
    $70.00
    Everolimus (159351-69-6) is a semisynthetic analog of rapamycin (Cat.# 10-1104) with potent immunosuppressive activity.1 Inhibits mTOR.2 Everolimus is a clinically useful immunosuppressant.3 References/Citations1)...

  • FH-535 | 108409-83-2 | Structure | Supplier
    $50.00
    FH-535 (108409-83-2) suppresses Wnt/β-catenin signaling. It antagonizes PPARγ and PPARδ ligand-dependent activation which is mediated by inhibition of recruitment of the coactivators β-catenin and GRIP1...

  • FLI-06 | Notch pathway inhibitor
    $80.00
    FLI-06 (313967-18-9) was discovered in a screen designed to monitor the trafficking and processing of a ligand-independent Notch-enhanced GFP reporter. It was found to disrupt the Golgi apparatus in a manner distinct from...

  • Forskolin | Adenylate cyclase activator
    $95.00
    Forskolin (66575-29-9) is a widely used adenylate cyclase activator.1 Forskolin also is a positive inotropic agent, vasodilator and induces platelet activation among other activities.2-5 References/Citations1) Awad et al...

  • GDC-0941 | pan-PI3K inhibitor
    $58.00
    GDC-0941 (957054-30-7) is a potent and selective inhibitor of class I phosphatidylinositol-3-kinases (PI3K) with significant antitumor activity – IC50’s: PI3Kα = 3nM, PI3Kβ = 33 nM, PI3Kδ = 3 nM,...

  • GW-5074 | c-Raf1 inhibitor
    $50.00
    GW-5074 (220904-83-6) is a potent inhibitor of cRAF1 kinase (IC50 = 9 nM). Displays 100-fold selectivity for cRAF1 over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. GW-5074 displays neuroprotective effects In...

  • Hypothemycin | MEK inhibitor
    $200.00
    Hypothemycin (76958-67-3) is a potent and selective inhibitor of MEK.1-3 Acts via covalent binding to Cys residue.2 In cells, hypothemycin inhibits the MEK-ERK axis with sufficient selectivity to normalize transformed...

  • ICG-001 | Wnt  beta-catenin inhibitor
    $65.00
    ICG-001 (847591-62-2) inhibits TCF/β-catenin mediated transcription by specifically blocking β-catenin/CBP interaction References/Citations 1) Emami et al. (2004), A small molecule inhibitor of...

  • iCRT-5 | 18623-44-4 | Structure | Supplier
    $57.00
    iCRT5 (18623-44-4) is a  selective CRT (β-catenin-responsive transcription) inhibitor.1  IC50=18 nM for Wnt responsive STF16 luciferase. Acts via interfering with the β-catenin, TCF4 interaction.1...

  • Importazole | 662163-81-7 | Structure | Supplier
    $75.00
    Importazole (662163-81-7) specifically inhibits importin-β-mediated nuclear import without disrupting transportin-mediated nuclear import or CRM1-mediated nuclear export.1 When added to cells during mitosis,...

  • Itraconazole | Autophagy inducer / Inhibits glioblastoma growth
    $40.00
    Itraconazole (84625-61-6) inhibits the conversion of lanosterol to ergosterol via inhibition of the 14-α demethylase, a cytochrome P-450 enzyme.1 Clinically useful antifungal agent. It inhibits the proliferation of...

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