my account
Login
  Loading... Please wait...

Product Details

Spautin-1 | Inhibits autophagy by inhibiting USP 10 and 13

Spautin-1 (1262888-28-7) is a specific and potent autophagy inhibitor. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific proteases USP10 and USP13 which target the Beclin-1 subunit of Vps34 complexes.1 Deranges dengue virion maturation.2 Spautin-1 inhibits autophagy in a Beclin-1 independent manner in primary epithelial ovarian cancer cells.3 Selectively induces cell death of mutant p53-expressing cancer cell lines under confluency.4 Cell permeable.

References/Citations
1) Liu et al. (2011), Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13; Cell, 147 223
2) Mateo et al. (2013), Inhibition of cellular autophagy deranges dengue virion maturation; J. Virol., 87 1312
3) Correa et al. (2014), Combination of AKT inhibition with autophagy blockade effectively reduces ascites-derived ovarian cancer cell viability; Carcinogenesis, Feb. 22, Epub.
4) Vakifahmetoglu-Norburg et al. (1987), Chaperone-mediated autophagy degrades mutant p53; Genes Dev.,
27 1718

swipe
Spautin-1 | 1262888-28-7 | Structure | Supplier

Catalog#  10-1367

$70.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
1262888-28-7
Catalog Number:
10-1367
Activity:
Inhibits autophagy by inhibiting USP 10 and 13
Chemical Name:
6-Fluoro-N[(4-fluorophenyl)methyl]-4-quinazolinamine
Molecular Weight:
271.27
Molecular Formula:
C15H11F2N3
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 15 mg/ml with warming).
Physical Properties:
Tan solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Share Focus

Connect with Focus

Click the button below to add the Spautin-1 | Inhibits autophagy by inhibiting USP 10 and 13 to your wish list.