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SR-9009 | RevErb alpha/beta agonist

CAS:
1379686-30-2
Catalog Number:
10-1511
Activity:
RevErbα/β agonist
Chemical Name:
Ethyl 3-(((4-chlorobenzyl)((5-nitrophen-2-yl)methyl)amino)methyl)pyrrolidine-1-carboxylate hydrochloride
Molecular Weight:
474.4
Molecular Formula:
C20H24CLN3O4S HCl
Solubility:
Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
Tan solid
Purity:
98% by TLC
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

SR-9009 (1379686-30-2) is an agonist at nuclear receptor Rev-ErbA.1 Greatly diminishes VILI-induced lung edema, inflammatory cell infiltration and TNFα production in a rat lung injury model.2 SR-9009 suppresses atherosclerosis in a mouse model.3  Specifically lethal to cancer cells and oncogene-induced senescent cells with no effect on the viability of normal cells or tissues.4 Disrupts pain associated with osteoarthritis by reducing BMAL1 expression in bmal1f/fNav1.8CreERT mice.5

References/Citations:

1) Solt et al. (2012) Regulation of circadian behavior and metabolism by synthetic REV-ERB agonists; Nature, 485 62
2) Li et al. (2014) A study on circadian rhythm disorder of rat lung tissue caused by mechanical ventilation induced lung injury; Int.Immunopharmacol. 18 249
3) Sitaula et al. (2015) Suppression of atherosclerosis by synthetic REV-ERB agonist; Biochem. Biophys. Res. Commun.,460 566
4) Sulli et al. (2018) Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence; Nature, 553 351
5) Das et al. (2018) Pharmacological targeting of the mammalian clock reveals a novel analgesic for osteoarthritis-induced pain; Gene 655 1

SR-9009 | RevErb alpha/beta agonist is also available in the Cellular Metabolism Library.
CAS:
1379686-30-2
Catalog Number:
10-1511
Activity:
RevErbα/β agonist
Chemical Name:
Ethyl 3-(((4-chlorobenzyl)((5-nitrophen-2-yl)methyl)amino)methyl)pyrrolidine-1-carboxylate hydrochloride
Molecular Weight:
474.4
Molecular Formula:
C20H24CLN3O4S HCl
Solubility:
Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
Tan solid
Purity:
98% by TLC
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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