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Self renewal/maintenance

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  • (±) Tranylcypromine hemisulfate | Demethylase inhibitor
    $40.00
    Tranylcypromine (13492-01-8) is an irreversible and non-selective monoamine oxidase inhibitor.1,2 It has been shown to inhibit the histone demethylase BHC110/LSD1.3,4 References/Citations1) Knoll et al. (1980), Monoamine...

  • 6BIO | 667463-62-9 | Structure | Supplier
    $65.00
    6BIO (667463-62-9) is a potent and selective inhibitor of glycogen synthase kinase-3 (GSK-3) IC50=5 nM.1 The first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells...

  • A83-01 | 909910-43-6 | Structure | Supplier
    $78.00
    A83-01 (909910-43-6) is a potent and selective ALK4, 5 and 7 inhibitor.1,2 IC50 = 45, 12 and 7.5 nM respectively. Prevents phosphorylation of Smad2/3 and growth inhibition induced by TGFβ.2 Inhibits...

  • CHIR-99021 potent and selective inhibitor
    $70.00
    CHIR-99021 (252917-06-9) is a potent and selective inhibitor of glycogen synthase kinase-3β (GSK3β, IC50 = 5 nM) and GSK3α (IC50 = 10 nM)1. Induces osteoblastogenesis, increases mineralization and inhibits...

  • Ethopropazine HCl | 1094-08-2 | Structure | Supplier
    $90.00
    Ethopropazine HCl (1094-08-2) is a butyrylcholinesterase inhibitor.1 Reduces drug-induced extrapyramidal motor syndrome. Parkinson's disease therapeutic.2 Alleviates thermal hyperalgesia in neuropathic rats...

  • GE-501516 | 317318-70-0 | Structure | Supplier
    $68.00
    GW-501516 (317318-70-0) is a potent and selective PPARδ (NR1C2) agonist, EC50=1.2 nM and 1000-fold selective over other PPAR subtypes.1  Induces apolipoprotein A1-mediated cholesterol efflux in vitro.1 Improves...

  • Go-6983 | PKC inhibitor
    $50.00
    Go-6983 (133053-19-7) potent and pan-specific, ATP-competitive protein kinase C inhibitor. PKC isotype IC50s= 7, 7, 6, 10 and 60 nM for PKC α, β, γ, δ, ζ respectively.1 Suppresses stress induced...

  • LY 294002 | PI 3-Kinase inhibitor
    $85.00
    LY 294002 (154447-36-6) is a potent and specific inhibitor of phosphatidylinositol-3-kinase (IC50 = 1.40 μM). References/Citations1) Vlahos et al. (1994) A specific inhibitor of phosphatidylinositol 3-kinase,...

  • MoTP | 57055-82-0 | Structure | Supplier
    $50.00
    MoTP (57055-82-0) specifically ablates zebrafish larval melanocytes. Melanocytotoxicity is dependent on tyrosinase activity1,2. MoTP is a useful tool for elucidating melanocyte stem cell regeneration, recruitment and...

  • PD 325901 MEK inhibitor
    $50.00
    PD 325901 (391210-10-9) is a selective Non-ATP-competitive MEK inhibitor (IC50 = 0.33nM)1. Inhibits growth and/or proliferation in a variety of cancer cells.2 PD 325901 enhances self-renewal of embryonic stem cells...

  • PD173074 | FGFR inhibitor
    $65.00
    PD173074 (219580-11-7)is an inhibitor of FGFR tyrosine kinase, and to a lesser extent VEGFR1 (IC50 values are 5 nM, 22.5 nM and 100 nM for FGFR1, FGFR3 and VEGFR respectively). Inhibition of FGFR by PD173074 promotes stem...

  • Pifithrin alpha | p53 inhibitor
    $50.00
    Pifithrin α (63208-82-2) is a reversible inhibitor of p53-mediated transcription and p53-dependent apoptosis. Enhances survival after genotoxic stress and protects against chemotherapeutic side-effects in mice.1,2...

  • Prostaglandin E2 | PGE2 | 363-24-6 | Structure | Supplier
    $25.00
    Prostaglandin E2 (363-24-6; PGE2) is an endogenous prostaglandin derived from the action of cyclooxygenase on arachidonic acid. PGE2 has diverse biological actions in the areas of inflammation, cancer, immune modulation,...

  • SB-216763 | GSK-3 inhibitor
    $70.00
    SB-216763 (280744-09-4) is a potent and selective inhibitor of glycogen synthase kinase-1 (GSK-3) IC50=34.3 nM1. Acts at the ATP-binding domain. Displays protective effects in lung fibrosis mouse model2. Displays...

  • SR1 | Maintains stem cells in pluripotent state
    $38.00
    SR1 (1227633-49-9) extends the pluripotency of hematopoietic stem cells (IC50 = 127 nM) by antagonizing AhR signaling resulting in continued expression of CD34. Effects are easily reversed by the removal of the SR1...

  • U0126 | Selective MEK1 and MEK2 inhibitor
    $99.00
    U0126 (109511-58-2) is a highly selective inhibitor of MEK1 and MEK2 in vitro and in vivo. Unlike PD98059 (Cat.# 10-2159), which only inhibits the activation of MEK1 and MEK2, U0126 inhibits both the active and inactive...

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