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Product Details

Terguride | Dopamine D2 agonist

Terguride (37686-84-3) is a semi-synthetic ergoline derivative which acts as a partial dopamine D2 agonist and 5HT2B/2C receptor antagonist. Displays antiparkinsonian effects in MPTP-treated cynomolgus monkeys1. Partial agonist at recruitment of β-arrestin2 to the D2 receptor2. Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats3.

References/Citations
1) Akai et al. (1993), Effects of terguride, a partial D2 agonist, on MPTP-lesioned parkinsonian cynomolgus monkeys; Ann. Neurol., 133 507
2) Klewe et al. (2008), Recruitment of beta-arrestin2 to the dopamine D2 receptor: insights into anti-psychotic and anti-parkinsonian drug receptor signaling; Neuropharmacology, 54 1215
3) Dumitrascu et al. (2011), Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats; Eur. Respir. J., 37 1104

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Catalog#  10-2308

$125.00
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CAS:
37686-84-3
Catalog Number:
10-2308
Activity:
Dopamine D2 agonist
Alternate Names:
S(+)-Terguride
Chemical Name:
S(+)-N,N-Diethyl-N'([8α]-6-methylergolin-8-yl)urea
Molecular Weight:
340.47
Molecular Formula:
C20H28N4O
Solubility:
Soluble in DMSO or in Ethanol.
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 3 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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