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NF-kB

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  • Andrographolide | 5508-58-7 | Structure | Supplier
    $34.00
    Andrographolide (5508-58-7) is the major bioactive component of the medicinal plant Andrographis paniculate. Demonstrates anti-inflammatory anti-apoptotic, anti-viral and anti-proliferative effects in vitro and in vivo...

  • CAPE | Inhibits NFkB activation
    $30.00
    CAPE (104594-70-9) is an antioxidant that inhibits NFκB activation and the growth of transformed cells. CAPE inhibits lipid peroxidation and displays antiinflammatory activity. Cell permeable. References/Citations1)...

  • Cardamonin | NFkB inhibitor
    $50.00
    Cardamonin (19309-14-9) inhibits NF-κB activation via inhibition of IκBα degradation and phosphorylation, IκB kinase activation and NF-κB nuclear translocation1,2. Cardamonin displays...

  • Celastrol | Proteasome inhibitor
    $116.00
    Celastrol (34157-83-0) displays potent antioxidant and anti-inflammatory activity. Inhibits NFkB (IC50=270 nM).  It induces heat shock response and cytoprotection in various cells. Inhibits 20S proteasome chymotrypsin...

  • DMAPT | NFkB inhibitor
    $58.00
    DMAPT (870677-05-7) is a water soluble analog of the natural plant product parthenolide (Cat.# 10-2096) which suppresses in vivo tumor growth of two tobacco-associated neoplasms, lung and bladder cancer. It inhibits...

  • Helenalin | NFkB inhibitor
    $238.00
    Helenalin (6754-13-8) is a novel sesquiterpene lactone which inhibits NFκB1 and displays potent anti-inflammatory activity2. It suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms3...

  • ML-239 | 1378872-36-6 | Structure | Supplier
    $65.00
    ML-239 (1378872-36-6) novel inhibitor of the growth and proliferation of breast cancer stem cells (CSC) discovered in a phenotypic screen employing CSC-like cells produced by inducing human breast epithelial cells into an...

  • NSC-697923 | 343351-67-7 | Structure | Supplier
    $50.00
    NSC-69723 (343351-67-7) is a selective inhibitor of E2 ubiquitin-conjugating enzyme, Ubc13-Uev1A. Does not inhibit UbcH5c activity. Impedes the formation of the Ubc13 and inhibits NF-κB activation in activated B...

  • Oxaprozin | 21256-18-8 | Structure | Supplier
    $70.00
    Oxaprozin (21256-18-8) is a clinically useful non-steroidal anti-inflammatory drug.1 In addition to typical NSAID COX inhibition, oxaprozin may also exert anti-inflammatory effects via inhibition of the Akt/IKK/NF-κB...

  • Rocaglamide | TNFalpha inhibitor
    $60.00
    Rocaglamide (84573-16-0) is a potent inhibitor of NFκB in T-lymphocytes with almost complete inhibition at 200nM.1  It was able to completely inhibit IL-4 and IFN-γ production and suppress 60-85% of IL-2 and...

  • SC-514 | 354812-17-2 | Structure | Supplier
    $65.00
    SC-514 (354812-17-2) is a reversible, competitive inhibitor of IKK2 (IC50 = 11.2 μM). Has not been demonstrated to inhibit other IKK isoforms, or other kinases. SC-514 displays dose-dependent inhibition of the...

  • SirtAct | Sirt1 activator
    $80.00
    SirtAct (839699-72-8) is a Sirt1 activator (233% at 10 μM)1 Suppresses TNFα release from THP-1 cells and stimulates adipogenesis in 3T3L1 cells1. SIRT1 stimulation by SirtAct leads to decreased tissue factor...

  • Sivelestat | 127373-66-4 | Structure | Supplier
    $50.00
    Sivelestat (127373-66-4) is a potent and selective leukocyte elastase inhibitor, IC50 = 44 nM1. Displays no activity at a variety of other proteases. Inhibits NF-κB activation2 and LTB4-induced neutrophil migration in...

  • Triptolide | Immunosuppressant
    $35.00
    Triptolide (38748-32-2) possesses potent immunosuppressive and anti-inflammatory activity.  Irreversibly inhibits eukaryotic transcription via covalent binding to XPB, a subunit of the transcription factor TFIIH.1...

  • Tryptanthrin | Immunomodulator; IDO2 inhibitor
    $50.00
    Tryptanthrin (13220-57-0) is an indoloquinazoline alkaloid found in various plant species and possessing intriguing pharmacological activities.1Suppresses activation of BV2 microglia cells following LPS treatment and reduces...

  • WY-14643 | 50892-23-4 | Structure | Supplier
    $60.00
    WY-14643 (50892-23-4) is a selective PPARα agonist (EC50=0.63, 32 and >100 µM for PPARα,γ and δ, respectively).1  Displays anti-inflammatory activity2 and reduces LPS-induced...

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