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Tropodithietic acid | Cytotoxic disulfide antibiotic

Tropodithietic acid (750590-18-2) displays potent broad-spectrum anticancer activity.1 Displays cytotoxic effects on mammalian cell lines (neuronal N2a cells and OLN-93 cells as model systems for nerve cells and glia) acting via disruption of mitochondrial membrane potential, activation of ERK1/2 and induction of HSP32/HO-1 (considered as a sensor of oxidative stress).2 A broad-spectrum antibiotic agent produced by marine bacteria which does not appear to induce resistance after long-term exposure.3

References/Citations

1) Wilson et al. (2016), Mode of action and resistance studies unveil new roles for tropodithietic acid as an anticancer agent and the γ-glutamyl cycle as a proton sink; Proc. Natl. Acad. Sci. USA, 113 1630
2) Wichmann et al. (2015), Cytotoxic Effects of Tropodithietic Acid on Mammalian Clonal Cell Lines of Neuronal and Glial Origin; Mar. Drugs, 13 7113
3) Rasmussen et al. (2016), Vibro anguillarum is Genetically and Phenotypically Unaffected by Long-Term Continuous Exposure to the Antibacterial Compound Tropodithietic Acid; Appl. Environ. Microbiol., 82 4802

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Catalog#  10-3307-0001

$150.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
750590-18-2
Catalog Number:
10-3307
Activity:
Cytotoxic disulfide antibiotic
Chemical Name:
Oxo-8,9-dithiabicyclo[5.2.0]non-1,4,6-triene-2-carboxylic acid
Molecular Weight:
212.25
Molecular Formula:
C8H4O3S2
Solubility:
Soluble in DMSO (up to 5 mg/ml)
Physical Properties:
Orange solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
FeaturedDescription:
Displays cytotoxic effects on mammalian cell lines via disruption of mitochondrial membrane potential, activation of ERK1/2 and induction of HSP32/HO-1.
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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