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Product Details

Vinblastine sulfate | Microtubule depolymerizer

Vinblastine sulfate (143-67-9) is a semisynthetic alkaloidal anticancer agent. Induces cell cycle arrest at G2/M phase by inhibiting mitotic spindle formation.1 Inhibits normal microtubule assembly and induces aberrant tubulin polymerization.1 Vinblastine sulfate induces apoptosis in a variety of cell lines.2 Inhibits autophagosome maturation.3 Inhibits palmitoylation of tubulin.4

References/Citations
1) Hamel et al. (1996), Antimitotic natural products and their interactions with tubulin; Med. Res. Rev., 16 207
2) Tsukidate et al. (1993), Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes; Am. J. Pathol., 143 918
3) Satori et al. (2013), Describing autophagy via analysis of individual organelles by capillary electrophoresis with laser induced fluorescence detection; Anal. Chem., 85 11391
4) Caron and Herwood (2007), Vinblastine, a chemotherapeutic drug, inhibits palmitoylation of tubulin in human leukemic lymphocytes; Chemotherapy, 53 51

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Catalog#  10-2050

$48.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
143-67-9
Catalog Number:
10-2050
Activity:
Microtubule depolymerizer
Alternate Names:
Vincaleukoblastine
Molecular Weight:
909.08
Molecular Formula:
C46H58N4O9 H2SO4
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Water (up to 50 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20&Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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