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Xanthohumol | VCP inhibitor / Autophagy inhibitor

CAS:
6754-58-1
Catalog Number:
10-1188
Activity:
VCP inhibitor / Autophagy inhibitor
Molecular Weight:
354.41
Molecular Formula:
C21H22O5
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 35 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Xanthohumol (6754-58-1) binds to the N-terminal domain of valosin-containing protein (VCP), an essential protein for autophagosome maturation. Xanthohumol inhibits the function of VCP thereby impairing autophagosome maturation and resulting in accumulation of the microtubule-associated protein 1 light chain 3-II (LC3-II)1. Impairs prostate cancer cell growth and proliferation2. Cell permeable.

References/Citations:

1) Sasazawa et al. (2012), Xanthohumol impairs autophagosome maturation through direct inhibition of valosin-containing protein; ACS Chem. Biol., 7 892
2) Vene et al. (2012), Xanthohumol impairs prostate cancer cell growth and invasion and diminishes the incidence and progression of advanced tumors in TRAMP mice; Mol. Med., 18 1292

Xanthohumol | VCP inhibitor / Autophagy inhibitor is also available in the Cellular Metabolism Library.
CAS:
6754-58-1
Catalog Number:
10-1188
Activity:
VCP inhibitor / Autophagy inhibitor
Molecular Weight:
354.41
Molecular Formula:
C21H22O5
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 35 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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