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Product Details

YM-254890 | Gq inhibitor

YM-254890 (568580-02-9) is a novel Gαq/11 inhibitor.1 U46619-induced platelet aggregation is inhibited but  phorbol ester- or ionophore-induced aggregation is not2 (IC50 = 0.1-0.2 μM)1. It blocks Pasteurella multocida toxin-mediated activation of Gαq.3 A highly useful new tool for studying Gαq/11-coupled receptor signaling and resulting cellular events.4

References/Citations

1) Takasaki (2004), A novel Galphaq/11-selective inhibitor; J. Biol. Chem., 279 47438
2) Uemura et al. (2006), Biological properties of a specific Galpha q/11 inhibitor, YM-254890, on platelet functions and thrombus formation under high-shear stress; Br. J. Pharmacol., 148 61
3) Orth et al. (2005), Pasteurella multocida toxin-induced activation of RhoA is mediated via two families of G{alpha} proteins, G{alpha}g and G{alpha}12/13; J. Biol. Chem., 280 36701
4) Mizuno and Itoh (2009), Functions and regulatory mechanisms of Gq-signaling pathways; Neurosignals, 17 42

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YM-254890 | 568580-02-9 | Structure | Supplier

Catalog#  10-1590-0100

$65.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
568580-02-9
Catalog Number:
10-1590
Activity:
Gq inhibitor
Source:
Isolated from Chromobacterium sp.
Molecular Weight:
960.1
Molecular Formula:
C46H69N7O15
Solubility:
Soluble in DMSO (up to 10 mg/ml)
Physical Properties:
White or off-white lyophilized solid
Purity:
95% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
FeaturedDescription:
Novel Gαq/11 inhibitor that inhibits U46619-induced platelet aggregation. A highly useful new tool for studying Gαq/11-coupled receptor signaling and resulting cellular events.
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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