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1,10-Phenanthroline HCl | Zn metalloprotease inhibitor

1,10-Phenanthroline (18851-33-7) is a high affinity chelator of divalent metal ions and may be used to inhibit zinc metalloenzymes.1  It is a potent inhibitor of JAMM-type isopeptidases (DUBs) acting via chelation of an active site Zn2+.  It may be used when preparing cell lysates for enrichment of ubiquitinated proteins  which are especially sensitive to DUBs in the JAMM family.2,3

References/Citations

1) Swann et al (1981) Zinc metalloenzyme properties of active and latent collagenase from rabbit bone;. Biochem.J., 195 41
2) Cooper et al. (2009) K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1; EMBO J., 28 621
3) Lu et al. (2015) Substrate degradation by the proteasome: A single-molecule kinetic analysis; Science, 348 200

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Catalog#  10-3017

$20.00
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CAS:
18851-33-7
Catalog Number:
10-3017
Activity:
Zn metalloprotease inhibitor
Alternate Names:
o-Phenanthroline hydrochloride hydrate
Molecular Weight:
234.68
Molecular Formula:
C13H8N2 • HCl &bul; H2O
Solubility:
Soluble in DMSO (up to 5 mg/ml) or in Water (up to 2 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 year as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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