my account
  Loading... Please wait...

Product Details

1,10-Phenanthroline HCl | Zn metalloprotease inhibitor

1,10-Phenanthroline (18851-33-7) is a high affinity chelator of divalent metal ions and may be used to inhibit zinc metalloenzymes.1  It is a potent inhibitor of JAMM-type isopeptidases (DUBs) acting via chelation of an active site Zn2+.  It may be used when preparing cell lysates for enrichment of ubiquitinated proteins  which are especially sensitive to DUBs in the JAMM family.2,3


1) Swann et al (1981) Zinc metalloenzyme properties of active and latent collagenase from rabbit bone;. Biochem.J., 195 41
2) Cooper et al. (2009) K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1; EMBO J., 28 621
3) Lu et al. (2015) Substrate degradation by the proteasome: A single-molecule kinetic analysis; Science, 348 200

Focus Biomolecules supplier, chemical structure of 1,10-Phenanthroline HCl | Zn metalloprotease inhibitor | CAS 18851-33-7

Catalog#  10-3017

Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
Request Bulk Quote
Catalog Number:
Zn metalloprotease inhibitor
Alternate Names:
o-Phenanthroline hydrochloride hydrate
Molecular Weight:
Molecular Formula:
C13H8N2 • HCl &bul; H2O
Soluble in DMSO (up to 5 mg/ml) or in Water (up to 2 mg/ml)
Physical Properties:
White solid
98% by TLC
NMR (Conforms)
Storage Temperature:
Stable for 2 year as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the 1,10-Phenanthroline HCl | Zn metalloprotease inhibitor to your wish list.