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Product Details

1,4-DPCA | Prolyl hydroxylase inhibitor

1,4-DPCA (331830-20-7) is a potent inhibitor of prolyl 4-hydroxylase (IC50=2-4 μM)1. Inhibits collagen deposition via inhibition of collagen proline hydroxylation2,3. Subcutaneous injection of a 1,4-DPCA containing hydrogel into Swiss Webster mice that do not show a regenerative phenotype increased expression of HIF1α over 5 days. Multiple injections led to regenerative wound healing after ear hole punch injury4.

References/Citations
1) Franklin et al. (2001), Inhibition of prolyl 4-hydroxylase in vitro and in vivo by members of a novel series of phenanthrolinones; Biochem. J., 353 333
2) Xiong et al. (2014), Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition; BMC Cancer, 14 1
3) Love and Jones et al. (2013), Transient inhibition of connective tissue infiltration and collagen deposition into porous poly(lactic-co-glycolic acid) discs; J. Biomed. Mater. Res., 101 3599
4) Zhang et al. (2015), Drug induced regeneration in adult mice; Sci. Transl. Med., 7 290ra92

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Catalog#  10-2956

$60.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
331830-20-7
Catalog Number:
10-2956
Activity:
Prolyl hydroxylase inhibitor
Chemical Name:
1,4-Dihydrophenonthrolin-4-one-3-carboxylic acid
Molecular Weight:
240.22
Molecular Formula:
C13H8N2O3
Solubility:
Soluble in DMSO (up to 15 mg/ml with warming).
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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