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2',3'-cGAMP | Endogenous STING agonist

2',3'-cGAMP (CAS 1441190-66-4) is an endogenous STING (stimulator of interferon genes) agonist.1 Produced from ATP and GTP via the action of cGMP-AMP synthase (cGAS) which acts as a cytosolic DNA sensor.2,3 Induces autophagy which is a mechanism for clearance of DNA and viruses in the cytosol.4 DNA damage stimulates 2’,3’-cGAMP which stimulates an inflammatory response.5

References/Citations

1) Zhang et al. (2015), Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING; Mol. Cell 51 226
2) Wu et al. (2013), Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA; Science 339 826
3) Sun et al. (2013), Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway; Science 339 786
4) Gui et al. (2019), Autophagy induction via STING trafficking is a primordial function of the cGAS pathway;  Nature, 567 262
5) Li and Chen (2018), The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence and cancer;  J. Exp. Med., 215 1287

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Catalog#  10-1639-0200

$95.00
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CAS:
1441190-66-4
Catalog Number:
10-1639
Activity:
Endogenous STING agonist
Chemical Name:
Adenylyl-(3’5’)-2’guanylic acid, cyclic nucleotide, disodium salt
Alternate Name:
2',3'cyclic GMP-AMP
Molecular Weight:
718.38
Molecular Formula:
C20H22N10O13P2·2Na
Solubility:
Soluble in DMSO (up to at least 25 mg/ml) or in Water (up to 10 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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