24(S),25-Epoxycholesterol | LXR agonist

24(S),25-Epoxycholesterol (77058-74-3) is a cholesterol metabolite that acts as an endogenous agonist for nuclear receptor LXR.¹ Controls cellular cholesterol homeostasis.² 24(S),25-Epoxycholesterol promotes neural development in zebra fish as well as dopaminergic differentiation of embryonic stem cells.³ Cell permeable.

References/Citations
1) Chawla et al. (2001), Nuclear receptors and lipid physiology: opening the X-files; Science, 294 1866
2) Brown et al. (2009), 24(S),25-epoxycholesterol: a messenger for cholesterol homeostasis; Int. J. Biochem. Cell Biol., 41 744
3) Theofilopoulos et al. (2013), Brain endogenous liver X receptor igands selectively promote midbrain neurogenesis; Nature Chem. Biol., 9 126