4-HQN | PARP inhibitor

4-HQN (491-36-1) is an inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50 = 9.5 μM).1 Displays mixed inhibition with respect to NAD+. Protective against ischemia-reperfusion induced ROS production, and subsequent mitochondrial and cell damage in rat heart.2 4-HQN is anti-inflammatory in LPS-induced endotoxic mice in vivo; decreases NF-κB and AP-1 activation.3

References/Citations

1) Banasil et al. (1992), Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase;  J. Biol. Chem., 267 1569
2) Halmosi et al. (2001), Effect of poly(ADP-ribose) polymerase inhibitors on the ischemia-reperfusion-induced oxidative cell damage and mitochondrial metabolism in Langendorff heart perfusion system.  Clin. Mol. Pharmacol., 59 1497
3) Veres et al. (2004), Regulation of kinase cascades and transcription factors by a poly(ADP-ribose) polymerase-1 inhibitor, 4-hydroxyquinazoline, in lipopolysaccharide-induced inflammation in mice;  J. Pharmacol. Exp. Ther., 310 247

Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
Size :

1 gram

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CAS:
491-36-1
Catalog Number:
10-1307
Activity:
PARP inhibitor
Chemical Name:
4-(1H)-Quinazolinone
Molecular Weight:
146.15
Molecular Formula:
C8H6N2O
Solubility:
Soluble in DMSO (up to 14 mg/ml) or in Water (up to 1 mg/ml).
Physical Properties:
White or off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
Shipping Code:
RT

4-HQN | PARP inhibitor

$30.00

CAS:
491-36-1
Catalog Number:
10-1307
Activity:
PARP inhibitor
Chemical Name:
4-(1H)-Quinazolinone
Molecular Weight:
146.15
Molecular Formula:
C8H6N2O
Solubility:
Soluble in DMSO (up to 14 mg/ml) or in Water (up to 1 mg/ml).
Physical Properties:
White or off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
Shipping Code:
RT
  • 1 gram
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