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Product Details

5alpha,6alpha-Epoxycholesterol | LXR ligand

5α,6α-Epoxycholesterol (1250-95-9) is a naturally occurring metabolite of cholesterol.  It is a major oxysterol found in processed food1 and has been implicated in atherosclerosis2,3. 5α,6α-Epoxycholesterol has been found to be an endogenous ligand for LXR (EC50 = 76 nM).4

References/Citations

1) Leonarduzzi et al. (2002), Oxidized products of cholesterol: dietary and metabolic origin, and proatherosclerotic effect (review); J. Nutr. Biochem., 13 700
2) Björkhem et al. (1988), Assay of unesterified cholesterol-5,6-epoxide in human serum by isotope dilution mass spectrometry. Levels in the healthy state and in hyperlipoproteinemia; J. Lipid Res., 29 1031
3) Staprans et al. (2005), The role of dietary oxidized cholesterol and oxidized fatty acids in the development of atherosclerosis; Mol. Nutr. Food Res., 49 1075
4) Berrodin et al. (2010), Identification of 5α,6α-Epoxycholesterol as a novel modulator of Liver X Receptor; Mol. Pharmacol., 78 1046

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Catalog#  10-4545

$25.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
1250-95-9
Catalog Number:
10-4545
Activity:
LXR ligand
Chemical Name:
Cholestan-5α,6α-epoxy-3β-ol
Molecular Weight:
402.65
Molecular Formula:
C27H46O2
Solubility:
Soluble in DMSO (up to 10 mg/ml) orin Ethanol (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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