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Product Details

6,7-ADTN HBr | Dopamine D1 agonist

6,7-ADTN HBr (13575-86-5) is a broad spectrum dopamine receptor agonist.1,2  Demonstrates a marked selectivity for the human dopamine D3 receptor.3 6,7-ADTN and psychostimulants such as cocaine and amphetamine reduce excitatory synaptic transmission in the nucleus accumbens by activating presynaptic dopamine receptors.4


1) List et al. (1982), Striatal binding of 2-amino-6,7-[3H]dihydroxy-1,2,3,4-tetrahydronaphthalene to two dopaminergic sites distinguished by their low and high affinity for neuroleptics; J. Neurosci., 2 895
2) Templeton et al. (1982), Binding of [3H]ADTN to rat striatal membranes; Biochem. Pharmacol., 31 1629
3) Freedman et al. (1994), Expression and pharmacological characterization of the human D3 dopamine receptor; Curr. J. Pharmacol. Exp. Ther., 268 417
4) Nicola et al. (1996), Psychostimulants depress excitatory synaptic transmission in the nucleus accumbens via presynaptic D1-like dopamine receptors; J. Neurosci., 16 1591

Focus Biomolecules cell signaling reagent supplier, chemical structure 6,7-ADTN HBr | Dopamine D1 agonist | CAS 13575-86-5

Catalog#  10-1607

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Catalog Number:
Dopamine D1 agonist
Chemical Name:
(+/-)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide
Alternate Names:
6-Amino-5,6,7,8-tetrahydronaphthalene-2,3-diol hydrobromide (racemic); NSC-287353
Molecular Weight:
Molecular Formula:
C10H13NO2 • HBr
Soluble in Water (up to 25 mg/ml)
Physical Properties:
Tan solid
98% by TLC
NMR (Conforms)
Storage Temperature:
Stable for 1 year as supplied. Solutions in distilled water may be stored at -20°C for up to 1 week.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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