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7,8-Dihydroxyflavone | TrkB agonist/neurotrophic

7,8-Dihydroxyflavone (38183-03-8) is a selective TrkB agonist (Kd=320 nM) with potent neurotrophic activity.1,2  Significantly improves motor deficits, ameliorates brain atrophy and extends survival in the well-characterized N171-82Q Huntington’s disease mouse model.3 Post-traumatic brain injury-treatment promotes neurogenesis in the hippocampus in a mouse model.4 Improves motor performance and motor neuronal survival in an ALS mouse model.5

1) Jang et al. (2010), A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone; Proc. Natl. Acad. Sci. USA, 107 2687
2) Liu et al. (2014) Biochemical and biophysical investigation of the brain-derived neurotrophic factor mimetic 7,8-dihydroxyflavone in the binding and activation of the TrkB receptor; J. Biol. Chem., 289 27571
3) Jiang et al. (2013) Small-molecule TrkB receptor agonist improve motor function and extend survival in a mouse model of Huntington’s disease; Hum. Mol. Genet., 22 2462
4) Zhao et al. (2016) Post-injury Treatment of 7,8-Dihydroxyflavone Promotes Neurogenesis in the Hippocampus of the Adult Mouse; J. Neurotrauma, 33 2055
5) Korkmaz et al. (2014) 7,8-dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis; Neurosci. Lett., 566 286

Focus Biomolecules cell signaling tech supplier, structure 7,8-Dihydroxyflavone | TrkB agonist/neurotrophic | CAS 38183-03-8

Catalog#  10-1174

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Catalog Number:
TrkB agonist/neurotrophic
Chemical Name:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 6 mg/ml).
Physical Properties:
Yellow or tan solid
98% by TLC
NMR (Conforms)
Storage Temperature:
Stable for 1 year as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 week.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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