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Product Details

Amiodarone HCl | PDE inhibitor

Amiodarone HCl (19774-82-4) is a pan-specific inhibitor of phosphodiesterases (IC50=2-50 μM). Inhibition of PDEs leads to increased concentration of intracellular cAMP which activates PKA2. Does not inhibit PDE8 or PDE93. Weak adenosine receptor antagonist4.

1) Yamase et al. (2012), Effectiveness of amiodarone verus bepridil in achieving conversion to sinus rhythm in patients with persistent atrial fibrillation: a randomized trial; Heart, 98 1067
2) Di Matola et al. (2000), Amiodrarone induces cytochrome c release and apoptosis through an iodine-independent mechanism; J. Clin. Endocrinol. Metab., 85 4323
3) Capell et al. (2011), Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase; J. Neurosci., 31 1885
4) Morissette et al. (2009), Intracellular sequestration of amiodarone: role of vacuolar ATPase and macroautophagic transition of the resulting vacuolar cytopathology; Br. J. Pharmacol., 157 1531

Focus Biomolecules cell signaling reagent supplier, chemical structure of Amiodarone HCl | PDE inhibitor | CAS 19774-82-4

Catalog#  10-2468

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Catalog Number:
PDE inhibitor
Chemical Name:
2-Butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride
Molecular Weight:
Molecular Formula:
C25H29I2NO3 HCl
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
White solid
98% by TLC
NMR (Conforms)
Storage Temperature:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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