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  • Alsterpaullone | 237430-03-4 | Structure | Supplier
    Alsterpaullone (237430-03-4) is a potent and selective inhibitor of GSK-3β and CDK5/p25. Potent inhibitor of CDK1/cyclin B (IC50 = 35 nM)1. Alsterpaullone induces apoptosis2 and inhibits angiogenesis3...

  • Borrelidin | 7184-60-3 | Structure | Supplier
    Novel macrolide which inhibits bacterial and eukaryotic threonyl-tRNA synthetase.1 Displays potent anti-angiogenic activity (IC50=0.8 nM) and induces the collapse of newly formed capillary tubules.2 Modulates alternative...

  • Bortezomib | Proteasome inhibitor
    Potent and selective proteasome inhibitor (Ki=0.6 nM). Inhibits proliferation of a number of tumor cell lines (IC50=7 nM).  Inhibits TNFα synthesis and FGF-induced angiogenesis. Clinically useful agent for...

  • Castanospermine | 79831-76-8 | Structure | Supplier
    Castanospermine (79831-76-8) is a natural product, derived from Castanospermum austral. Potent inhibitor of α- and β-glucosidases.1 Exhibits antiviral properties.2 Inhibits HIV infectivity.3 Inhibits thyroglobulin...

  • Ciglitazone | 74772-77-3 | Structure | Supplier
    Ciglitazone (74772-77-3) is a PPARγ agonist (EC50=3 μM). Stimulates adipogenesis in human mesenchymal stem cells. Ciglitazone inhibits HUVEC differentiation and angiogenesis. Cell permeable. References/Citations1)...

  • Damnacanthal | p56 Lck inhibitor
    Damnancantal (477-84-9) is a potent inhibitor of p56lck tyrosine kinase activity (IC50 = 17 nM for inhibition of autophosphorylation). Displays 7- to 20-fold selectivity over p59fyn and p60src tyrosine kinases and >...

  • DZNep | 102052-95-9 | Structure | Supplier
    DZNep (102052-95-9) is a potent histone methyltransferase inhibitor which decreases global histone methylation.1 Inhibits trimethylation of H3K27 and H4K20 in vitro.1 Selectively induces apoptosis in multiple cancer cell...

  • Fascaplysin | 114718-57-2 | Structure | Supplier
    Fascaplysin (114719-57-2) is a novel marine natural product isolated from Thorectandra sp.1 A potent and selective inhibitor of cyclin dependent kinase 4/cyclin D1 (IC50 = 0.35 μM) and is less selective for Cdk6/D1...

  • Indirubin-3'-monoxime | 160807-49-8 | Structure | Supplier
    Indirubin-3'-monoxime (160807-49-8) is a potent GSK-3β inhibitor (IC50=22 nM)1. Also inhibits CDK1 (IC50=180 nM) and CDK5 (IC50=100 nM)1. Displays antimitotic properties and induces endoreplication following prophase...

  • P5091 | 882257-11-6 | Structure | Supplier
    P5091 (882257-11-6) is a selective inhibitor of the ubiquitin-specific protease USP7 ( IC50=4.2 μM)1,2. Induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance1. P5091 displays antiangiogenic...

  • Picropodophyllotoxin | IGF1R inhibitor
    Picropodophyllotoxin (477-47-4) is a potent and selective inhibitor of insulin-like growth factor 1 receptor (IGF1R) which is non-competitive with ATP.1 Displays no activity at IR, EGFR, FGFR or PDGFR. Inhibits IGF1R...

  • Radicicol | HSP90 inhibitor
    Radicicol (12772-57-5) inhibits heat shock protein 90 (HSP90) activity by binding to the ATP-binding pocket.1 In cells HSP90 client proteins such as Raf kinase2, HIF-1α3 and estrogen receptor4 are destabilized and...

  • Roscovitine | 186692-46-6 | Structure | Supplier
    Roscovitine (186692-46-6) is a potent and selective inhibitor of cyclin-dependent kinases displaying higher potency and selectivity compared to olomoucine.  p34 cdc2 IC50 = 0.2 µM.  Also inhibits p33cdk2 and...

  • Sorafenib | Inhibitor of Raf-1 and other kinases
    Sorafenib (475207-59-1; base) was initially developed as a Raf kinase inhibitor, IC50 = 6 nM, but has been shown to inhibit many receptor tyrosine kinases including BRAF (IC50 = 22 nM); VEGFR-2 (IC50 = 90 nM); VEGFR-3 (IC50...

  • Sphingosine-1-phosphate | EDG receptor ligand
    Sphingosine-1-phosphate (26993-30-6) is an endogenous sphingolipid metabolite known to be involved in many cellular responses including angiogenesis, vascular maturation, cardiac development and immunity. These effects are...

  • SRPIN340 | 218156-96-8 | Structure | Supplier
    SRPIN340 (218156-96-8) is a selective serine arginine protein kinase (SRPK) 1 inhibitor (Ki = 0.89 μM).1 Inhibits SRPK2 at higher concentrations. Does not significantly inhibit other SRPKs such as CLK1 and CLK4, or other...

  • Temozolomide | Autophagy inducer
    Temozolomide (85622-93-1) is a DNA alkylating agent with antitumor and antiangiogenic activity.1,2 Clinically useful anticancer agent.3 Temozolomide induces autophagy in a variety of cell lines.4 Cell...

  • Terazocin HCl | Adrenergic antagonist
    Terazocin HCl (63074-08-8) is an α1- and α2B-adrenoceptor antagonist (Ki = 3.3, 0.7, 1.1, 7.7, 1510 and 78.2 nM for α1A, α1B, α1D, α2B, α2A and α2C receptors respectively)1...

  • Ursolic Acid | Angiogenesis inhibitor
    Ursolic acid (77-52-1) inhibits endothelial cell proliferation and migration (IC50=5 µM) and angiogenesis.1 Promotes skeletal muscle rejuvenation via enhanced SIRT1 expression.2 Induces apoptosis in malignant...

  • WEB-2086 | 105219-56-5 | Structure | supplier
    WEB-2086 (105219-56-5) is a potent and selective antagonist of the platelet activating factor (PAF) receptor (Ki = 16.3 nM).1 Displays an activity profile which includes antiinflammatory, antiangiogenesis and anticancer...

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