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  • Focus Biomolecules supplier, chemical structure of Alsterpaullone | GSK3b inhibitor and CDK5/p25 inhibitor | CAS 237430-03-4
    $56.00
    Alsterpaullone (237430-03-4) is a potent and selective inhibitor of GSK-3β and CDK5/p25. Potent inhibitor of CDK1/cyclin B (IC50 = 35 nM)1. Alsterpaullone induces apoptosis2 and inhibits angiogenesis3...

  • Focus Biomolecules supplier, chemical structure of Borrelidin | Angiogenesis inhibitor | CAS 7184-60-3
    $190.00
    Novel macrolide which inhibits bacterial and eukaryotic threonyl-tRNA synthetase.1 Displays potent anti-angiogenic activity (IC50=0.8 nM) and induces the collapse of newly formed capillary tubules.2 Modulates alternative...

  • Focus Biomolecules supplier, chemical structure of Bortezomib | Proteasome inhibitor | CAS 179324-69-7
    $50.00
    Potent and selective proteasome inhibitor (Ki=0.6 nM). Inhibits proliferation of a number of tumor cell lines (IC50=7 nM).  Inhibits TNFα synthesis and FGF-induced angiogenesis. Clinically useful agent for...

  • Focus Biomolecules cell signaling reagent supplier, structure of Castanospermine | Glucosidase inhibitor | CAS 79831-76-8
    $80.00
    Castanospermine (79831-76-8) is a natural product, derived from Castanospermum austral. Potent inhibitor of α- and β-glucosidases.1 Exhibits antiviral properties.2 Inhibits HIV infectivity.3 Inhibits thyroglobulin...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Ciglitazone | PPARŒ≥ agonist | CAS 74772-77-3
    $80.00
    Ciglitazone (74772-77-3) is a PPARγ agonist (EC50=3 μM). Stimulates adipogenesis in human mesenchymal stem cells. Ciglitazone inhibits HUVEC differentiation and angiogenesis. Cell permeable. References/Citations1)...

  • Damnacanthal | p56 Lck inhibitor
    $130.00
    Damnancantal (477-84-9) is a potent inhibitor of p56lck tyrosine kinase activity (IC50 = 17 nM for inhibition of autophosphorylation). Displays 7- to 20-fold selectivity over p59fyn and p60src tyrosine kinases and >...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure DZNep | Methyltransferase inhibitor | CAS 102052-95-9
    $142.00
    DZNep (102052-95-9) is a potent histone methyltransferase inhibitor which decreases global histone methylation.1 Inhibits trimethylation of H3K27 and H4K20 in vitro.1 Selectively induces apoptosis in multiple cancer cell...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Fascaplysin | CDK4 inhibitor | CAS 114718-57-2
    $40.00
    Fascaplysin (114719-57-2) is a novel marine natural product isolated from Thorectandra sp.1 A potent and selective inhibitor of cyclin dependent kinase 4/cyclin D1 (IC50 = 0.35 μM) and is less selective for Cdk6/D1...

  • Focus Biomolecules supplier, chemical structure of Indirubin-3'-monoxime | GSK-3 beta and CDK inhibitor | CAS 160807-49-8
    $60.00
    Indirubin-3'-monoxime (160807-49-8) is a potent GSK-3β inhibitor (IC50=22 nM)1. Also inhibits CDK1 (IC50=180 nM) and CDK5 (IC50=100 nM)1. Displays antimitotic properties and induces endoreplication following prophase...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of P5091 | DUB USP7 inhibitor | CAS 882257-11-6
    $60.00
    P5091 (882257-11-6) is a selective inhibitor of the ubiquitin-specific protease USP7 ( IC50=4.2 μM)1,2. Induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance1. P5091 displays antiangiogenic...

  • Focus Biomolecules supplier, chemical structure of Picropodophyllotoxin | IGF-1R inhibitor | CAS 477-47-4
    $80.00
    Picropodophyllotoxin (477-47-4) is a potent and selective inhibitor of insulin-like growth factor 1 receptor (IGF1R) which is non-competitive with ATP.1 Displays no activity at IR, EGFR, FGFR or PDGFR. Inhibits IGF1R...

  • Pomalidomide | Cereblon ubiquitination inhibitor
    $50.00
    Thalidomide analog. Inhibits cereblon (CRBN) an E3 ubiquitin ligase, IC50 ~3 μM for CRBN-DDB1 complex.1 Displays antiangiogenic and immunomodulatory activity in vivo potently inhibiting the production of TNFα and...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Radicicol | HSP90 inhibitor | CAS 12772-57-5
    $50.00
    Radicicol (12772-57-5) inhibits heat shock protein 90 (HSP90) activity by binding to the ATP-binding pocket.1 In cells HSP90 client proteins such as Raf kinase2, HIF-1α3 and estrogen receptor4 are destabilized and...

  • Focus Biomolecules cell signaling reagent supplier, structure of Roscovitine | p34/cdc2 inhibitor | CAS 186692-46-6
    $35.00
    Roscovitine (186692-46-6) is a potent and selective inhibitor of cyclin-dependent kinases displaying higher potency and selectivity compared to olomoucine.  p34 cdc2 IC50 = 0.2 µM.  Also inhibits p33cdk2 and...

  • Focus Biomolecules supplier, chemical structure of Sorafenib | Inhibitor of Raf-1 and other kinases | CAS 475207-59-1
    $40.00
    Sorafenib (475207-59-1; base) was initially developed as a Raf kinase inhibitor, IC50 = 6 nM, but has been shown to inhibit many receptor tyrosine kinases including BRAF (IC50 = 22 nM); VEGFR-2 (IC50 = 90 nM); VEGFR-3 (IC50...

  • Focus Biomolecules supplier, chemical structure of Sphingosine-1-phosphate | EDG receptor ligand | CAS 26993-30-6
    $65.00
    Sphingosine-1-phosphate (26993-30-6) is an endogenous sphingolipid metabolite known to be involved in many cellular responses including angiogenesis, vascular maturation, cardiac development and immunity. These effects are...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of SRPIN340 | SRPK inhibitor | CAS 218156-96-8
    $68.00
    SRPIN340 (218156-96-8) is a selective serine arginine protein kinase (SRPK) 1 inhibitor (Ki = 0.89 μM).1 Inhibits SRPK2 at higher concentrations. Does not significantly inhibit other SRPKs such as CLK1 and CLK4, or other...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Temozolomide | Autophagy inducer | CAS 85622-93-1
    $75.00
    Temozolomide (85622-93-1) is a DNA alkylating agent with antitumor and antiangiogenic activity.1,2 Clinically useful anticancer agent.3 Temozolomide induces autophagy in a variety of cell lines.4 Cell...

  • Focus Biomolecules cell signaling tech supplier, chemical structure Terazocin HCl | Adrenergic antagonist | CAS 63074-08-8
    $50.00
    Terazocin HCl (63074-08-8) is an α1- and α2B-adrenoceptor antagonist (Ki = 3.3, 0.7, 1.1, 7.7, 1510 and 78.2 nM for α1A, α1B, α1D, α2B, α2A and α2C receptors respectively)1...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Ursolic Acid | Angiogenesis inhibitor | CAS 77-52-1
    $40.00
    Ursolic acid (77-52-1) inhibits endothelial cell proliferation and migration (IC50=5 µM) and angiogenesis.1 Promotes skeletal muscle rejuvenation via enhanced SIRT1 expression.2 Induces apoptosis in malignant...

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