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Withaferin A | NFkB and angiogenesis inhibitor

CAS:
5119-48-2
Catalog Number:
10-2114
Activity:
NFκB and angiogenesis inhibitor
Chemical Name:
(4β, 5β, 6β, 22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic acid δ-lactone
Molecular Weight:
470.60
Molecular Formula:
C28H38O6
Solubility:
Soluble in DMSO (up to 20 mg/ml)
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Withaferin A (5119-48-2) displays potent antiangiogenesis activity inhibiting endothelial cell sprouting in vitro (IC50 = 12 nM) and in vivo.1 Potently inhibits NF-κB activation by preventing TNFα-induced activation of IKKβ.2 Covalently binds to the intermediate filament protein, vimentin3 inducing its disassembly and serine 56 phosphorylation4. Inhibits reactive gliosis and blocks TNFα-mediated neuronal apoptosis in in vivo models.5

 References/Citations:

1) Mohan et al. (2004), Withaferin A is a potent inhibitor of angiogenesis; Angiogenesis, 7 115
2) Kaileh et al. (2007), Withaferin A strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with inhibition of its kinase activity; J. Biol. Chem., 282 4253
3) Bargagna-Mohan et al. (2007), The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin; Chem. Biol., 14 623
4) Thaiparambil et al. (2011), Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation; Int. J. Cancer, 129 2744
5) Livne-Bar et al. (2016), Pharmacologic inhibition of reactive gliosis blocks TNF-α-mediated neuronal apoptosis; Cell Death Dis., 7 e2386

Withaferin A | NFkB and angiogenesis inhibitor is also available in the Cellular Metabolism Library.
CAS:
5119-48-2
Catalog Number:
10-2114
Activity:
NFκB and angiogenesis inhibitor
Chemical Name:
(4β, 5β, 6β, 22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic acid δ-lactone
Molecular Weight:
470.60
Molecular Formula:
C28H38O6
Solubility:
Soluble in DMSO (up to 20 mg/ml)
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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