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  • Focus Biomolecules supplier, chemical structure of 6-Thioguanine | Anticancer agent | Downregulates DNMT1 | CAS 154-42-7
    6-Thioguanine | Anticancer agent / Downregulates DNMT1
    $30.00
    6-Thioguanine (154-42-7) is a methyltransferase inhibitor.  After incorporation into DNA, it disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.1 It...

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  • 9-Hydroxyrisperidone | Risperidone metabolite
    9-Hydroxyrisperidone | Risperidone metabolite
    $30.00
    9-Hydroxyrisperidone (144598-75-4) is a pharmacologically active metabolite of risperidone, an atypical antipsychotic agent.1 Displays high affinity for serotonin 5-HT2A receptors as well as dopamine D2 receptors...

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  • Abemaciclib | Potent and selective CDK 4/6 inhibitor
    Abemaciclib | Potent and selective CDK 4/6 inhibitor
    $50.00
    Abemaciclib (1231930-82-7) is a potent and selective CDK4/6 inhibitor (IC50 = 2 nM and 10 nM respectively).1 It caused G1 cell cycle arrest in colo-205 colorectal cells, MDA-MB-361 breast cancer cells, and MV4-11 AML cells...

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  • Acalabrutinib | Highly selective BTK inhibitor
    Acalabrutinib | Highly selective BTK inhibitor
    $45.00
    Acalabrutinib (1420477-60-6) is a highly selective, potent (IC50 = 3 nM), and irreversible inhibitor of Bruton’s tyrosine kinase (BTK).1 Improved target selectivity (especially against TEC family kinases and EGFR)...

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  • Focus Biomolecules cell signaling supplier, chemical structure of Afatinib | EGFR, HER2 inhibitor | CAS 850140-72-6
    Afatinib | EGFR and HER2 inhibitor
    $85.00
    Afatinib (850140-72-6) is a clinically useful kinase inhibitor approved for the treatment of non-small cell lung cancer. It is a potent and highly selective inhibitor of mutant and wild-type EGFR (IC50= 0.5 nM) and HER2...

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  • Alectinib | Potent and selective ALK inhibitor
    Alectinib | Potent and selective ALK inhibitor
    $60.00
    Alectinib (1256580-46-7) is a potent (IC50 = 1.9 nM) and highly selective ALK inhibitor.1 It blocked phosphorylation of both native ALK and the L1196M, C1156Y, and F1174L mutants. Alectinib has also been shown to inhibit RET...

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  • Allopregnanolone | GABA-A positive allosteric modulator
    Allopregnanolone | GABA-A positive allosteric modulator
    $70.00
    Allopregnanolone (516-54-1) is an endogenous neurosteroid which acts as a positive allosteric modulator of GABAA receptors.1,2 Recently FDA approved (Brexanolone) for postpartum depression.3 Inhibits TLR4 receptor activation...

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  • Focus Biomolecules cell signaling tech supplier, chemical structure Ambroxol HCl | Free radical scavenger | CAS 18683-91-5
    Ambroxol HCl | Free radical scavenger
    $50.00
    Ambroxol HCl (18683-91-5) is a radical scavenger with anti-inflammatory activity. Blocks the generation of reactive oxygen species by bronchoalveolar lavage cells, inhibits doxorubicin-induced lipid peroxidation (70 mg/kg in...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Amifostine | Cellular protectant | CAS 20537-88-6
    Amifostine | Cellular protectant
    $56.00
    Amifostine (20537-88-6) is a broad sprectrun radio- and chemoprotective agent.1 Prevents chemotherapy-induced apoptosis, upregulates HIF-1α and restores transcriptional activity in specific p53 mutants.2-4...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Amiodarone HCl | PDE inhibitor | CAS 19774-82-4
    Amiodarone HCl | Pan-specific ion channel blocker
    $45.00
    Amiodarone HCl (19774-82-4) is a nonselective ion channel blocker. Class III antiarrhythmic.1 Induces cytochrome c release and induces apoptosis.2 An alkalizing agent which stimulates progranulin (GRN) production and...

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  • Anagrelide HCl | PDE3 inhibitor
    Anagrelide HCl | PDE3 inhibitor
    $48.00
    Anagrelide HCl (58579-51-4) is a potent and selective phosphodiesterase (PDE3) inhibitor, IC50=36 nM).1 Inhibits platelet production by disrupting megakaryocyte maturation2 via a mechanism which is independent of PDE3...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure Apomorphine HCl | Dopamine agonist | CAS 41372-20-7
    Apomorphine HCl | Dopamine agonist
    $40.00
    Apomorphine (41372-20-7) is an archetypal dopamine pan-receptor agonist. Displays anti-Parkinsons activity in vivo.1 Protects against MPTP-induced neurotoxicity in a mouse model.2 In clinical use for Parkinson’s...

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  • Focus Biomolecules supplier, chemical structure of Aripiprazole | Dopamine receptor partial agonist | CAS 129722-2-9
    Aripiprazole | Dopamine receptor partial agonist
    $40.00
    Aripiprazole (129722-2-9) is a clinically useful neuroleptic and antipsychotic agent.1 Dopamine D2 receptor antagonist and autoreceptor agonist.2 Improves symptoms of psychosis associated with Alzheimer's disease...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Auranofin | IKK inhibitor | CAS 34031-32-8
    Auranofin | IKK inhibitor
    $50.00
    Auranofin (34031-32-8) is a disease-modifying antirheumatic drug (DMARD) , It is a potent inhibitor of selenoenzyme thioredoxin reductase and IκB kinase (IKK) by modifying Cys-179. Auranofin is an efficient inducer of...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure Axitinib | VEGFR kinase inhibitor | CAS 319460-85-0
    Axitinib | VEGFR kinase inhibitor
    $40.00
    Potent inhibitor of VEGFR-2, -3, and -1, IC50 = 0.2, 0.1-0.3, and 1.2 nM respectively1 displaying minimal activity against a panel of ~100 protein kinases. Inhibits angiogenesis and vascular permeability.2 Also inhibits...

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  • Baricitinib | JAK 1/2 inhibitor
    Baricitinib | JAK 1/2 inhibitor
    $50.00
    Baricitinib (1187594-09-7), approved by the FDA for two inflammatory disorders, rheumatoid arthritis and alopecia areata, selectively inhibits Janus kinase 1 (IC50 = 5.9 nM) and 2 (5.7 nM), over 3 (0.56 µM).1 It...

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  • Binimetinib | MEK1/2 inhibitor
    Binimetinib | MEK1/2 inhibitor
    $39.00
    Binimetinib (606143-89-9) is a potent (IC50 = 12 nM) and selective allosteric inhibitor of MEK1/2.1,2 Recently approved by the FDA for treatment of melanoma in combination with Encorafenib. Binimetinib has had limited...

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  • Focus Biomolecules supplier, chemical structure of Bleomycin sulfate | Induces double strand DNA breaks | CAS 9041-93-4
    Bleomycin sulfate | Induces double strand DNA breaks
    $90.00
    Bleomycin sulfate (9041-93-4) coordinates with metals producing reactive oxygen species which causes oxidative damage to DNA1 and RNA2. Induces double-strand DNA damage.3 Commonly used to induce lung fibrosis in animal...

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  • Focus Biomolecules reagent supplier, chemical structure Captopril | Angiotensin-converting enzyme inhibitor | CAS 62571-86-2
    Captopril | Angiotensin-converting enzyme inhibitor
    $30.00
    Captopril (62571-86-2) is an angiotensin-converting enzyme (ACE) inhibitor (IC50 = 0.022 μM).1 Also inhibits the bifunctional Zn2+-containing leukotriene A4 hydrolase/aminopeptidase (LTA4 hydrolase) reversibly and...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Cilostazol | PDE3A inhibitor | CAS 73963-72-1
    Cilostazol | PDE3A inhibitor
    $40.00
    Cilostazol (73963-72-1) is a clinically approved phosphodiesterase III (PDE3) inhibitor (IC50 = 0.2 μM) and anti-thrombotic agent. It inhibits platelet aggregation and is a direct arterial vasodilator...

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