Aripiprazole | Dopamine receptor partial agonist

CAS:
129722-12-9
Catalog Number:
10-2314
Activity:
Dopamine receptor partial agonist
Alternate Names:
OPC-14597
Chemical Name:
7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone
Molecular Weight:
448.4
Molecular Formula:
C23H27Cl2N3O2
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
20 mg$40.00
100 mg$100.00

Aripiprazole (129722-12-9) is a clinically useful neuroleptic and antipsychotic agent.1 Dopamine D2 receptor antagonist and autoreceptor agonist.Improves symptoms of psychosis associated with Alzheimer’s disease.3 Aripiprazole blocked cocaine-seeking behavior without affecting other rewarding behaviors in animal models.4

References/Citations:

1) Green et al. (2004), Focus on aripiprazole; Curr. Med. Res. Opin., 20 207
2)
Kikuchi et al. (1995), 7-(4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro-2(1H)-quinolinone (OPC-14597), a new putative antipsychotic drug with both presynaptic dopamine autoreceptor agonistic activity and postsynaptic D2 receptor antagonistic activity; J. Pharmacol. Exp. Ther., 274 329
3)
Madhusoodanan et al. (2008), Management of psychosis in patients with Alzheimer’s disease: focus on aripiprazole; Clin. Interv. Aging, 3 491
4)
Feltenstein et al. (2007), Aripiprazole blocks reinstatement of cocaine seeking in an animal model of relapse; Biol. Psychiatry, 61 582

CAS:
129722-12-9
Catalog Number:
10-2314
Activity:
Dopamine receptor partial agonist
Alternate Names:
OPC-14597
Chemical Name:
7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone
Molecular Weight:
448.4
Molecular Formula:
C23H27Cl2N3O2
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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