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Prostaglandin E1 | Vasodilator

CAS:
745-65-3
Catalog Number:
10-4455
Activity:
Vasodilator
Chemical Name:
(11a, 13E,15S)-11,15-Dihydroxy-9-oxo-prost-13-en-1-oic acid
Alternate Names:
PGE1; Alprostadil
Molecular Weight:
354.49
Molecular Formula:
C20H34O5
Solubility:
Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 15 mg/ml)
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
Blue Ice

PGE1 (745-65-3) is an endogenous prostaglandin with vasodilatory, anti-platelet, and anti-hypertensive activities.1,2 It is in clinical use for the treatment of erectile dysfunction3 and the emergency management of infants with patent ductus arteriosus4. It has also been used in the treatment of peripheral arterial occlusive disease (PAD).5

References/Citations:

1) Kirtland (1988) Prostaglandin E1: 1 review; Prostaglandins Leukot. Essent. Fatty Acids, 32 165
2) Schermuly et al. (2005) Prostanoids and Phosphodiesterase Inhibitors in Experimental Pulmonary Hypertension; Curr. Top. Dev. Biol. 67 251
3) Urciuoli et al (2004) Prostaglandin E1 for treatment of erectile dysfunction; Cochrane Database Syst. Rev. CD001784
4) Huang et al. (2013) Reappraisal of the prostaglandin E1 dose for early newborns with patent ductus arteriosus-dependent pulmonary circulation; Pediatr. Neonatol. 54 102
5) Schroer and Hohlfeld (2004) Mechanisms of anti-ischemic action of prostaglandin E1 in peripheral arterial occlusive disease; Vasa 33 119

Prostaglandin E1 | Vasodilator is also available in the Cellular Metabolism Library.
CAS:
745-65-3
Catalog Number:
10-4455
Activity:
Vasodilator
Chemical Name:
(11a, 13E,15S)-11,15-Dihydroxy-9-oxo-prost-13-en-1-oic acid
Alternate Names:
PGE1; Alprostadil
Molecular Weight:
354.49
Molecular Formula:
C20H34O5
Solubility:
Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 15 mg/ml)
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
Blue Ice

Safety Data Sheet:

N/A

Product Data Sheet:

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