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  • Focus Biomolecules cell signaling tech supplier, chemical structure of Antibiotic A-23187 | Ca2+ ionophore | CAS 52665-69-7
    Antibiotic A-23187 (52665-69-7) is a highly selective divalent cation ionophore, commonly used to increase intracellular Ca2+ levels in intact cells (though it is most selective for Mn2+).1 It uncouples oxidative...

  • Focus Biomolecules reagent supplier, chemical structure of Bafilomycin A1 | Vacuolar H+ ATPase inhibitor | CAS 88899-55-2
    Bafilomycin A1 (88899-55-2) is a macrolide antibiotic derived from Streptomyces griseus that is a potent and selective inhibitor of vacuolar H+-ATPases (IC50 = 0.6 – 1.5 nM).1,2 Bafilomycin A1 inhibits autophagy via...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of DBeQ | p97 inhibitor | CAS 177355-84-9
    DBeQ (177355-84-9) is a potent, selective and reversible inhibitor of the AAA-ATPase p97 (ATPase associated with diverse cellular activities). Ki=3.2 μM. DBeQ blocks ubiquitin-dependent protein clearance pathways. Cell...

  • Focus Biomolecules supplier, chemical structure of Manzamine A | Inhibitor of vacuolar ATPases | CAS 104196-68-1
    Manzamine A (104196-68-1) inhibits vacuolar ATPases and inhibits autophagy in pancreatic cancer cells1. Suppresses atherosclerosis in vivo2. Manzamine A displays neuritogenic activity3 and suppresses tau...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of MDBN | p97 inhibitor | CAS 1485-00-3
    MDBN (1485-00-3) is an irreversible inhibitor of p97 (IC50 < 10 μM). Cell permeable References/Citations1) Chou et al. (2011), Quantitative cell-based protein degradation assays to identify and classify drugs that...

  • Focus Biomolecules supplier, chemical structure of Nigericin Na | Induces rapid intracellular acidification | CAS 28643-80-3
    Nigericin Na (28643-80-3) is a polyether ionophore which disrupts membrane potential and stimulates ATPase activity in mitochondria. Induces apoptosis resulting from intracellular acidification. Ion selectivity for nigericin...

  • Focus Biomolecules supplier, chemical structure of Oligomycin Complex | Mitochondrial ATPase inhibitor | CAS 1404-19-9
    Oligomycin (1404-19-9) inhibits mitochondrial F1F0 ATP synthase.1 A useful tool for decreasing cellular ATP levels.2 Induces autophagy.3 Stimulates lysosome acidification.4 Oligomycin protects against ischemic kidney in male...

  • Focus Biomolecules cell signaling reagent supplier, structure of Ouabain | Na+/K+ ATPase inhibitor | CAS 11018-89-6
    Ouabain (11018-89-6) is a selective inhibitor of Na+ K+-ATPase isolated from Strophanthus gratus1. Endogenous ouabain is found in human circulation2. Displays cardiotonic and diuretic activity. May be used to induce...

  • Focus Biomolecules, chemical structure S-Farnesyl-L-cysteine methyl ester | MDR transporter activator | CAS 125741-64-2
    S-Farnesyl-L-cysteine methyl ester (125741-64-2) stimulates multidrug resistance transporter ATPase activity (4-5 fold at 10-20 µM) and competes for drug binding.1 It modifies the carboxyl terminus of the Saccharomyces...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Thapsigargin | SERCA inhibitor | CAS 67526-95-8
    Thapsigargin (67526-95-8) is a potent inhibitor of sarco-endoplasmic reticulum Ca2+ -ATPase1. (IC50= 30 nM) Induces endoplasmic reticulum stress and autophagy in a variety of cell lines2. Warning: Thapsigargin is highly...

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