Modify Search
Select all
Products
Pages
Posts
Modify Search
Select all
Products
Pages
Posts

Concanamycin A | V-ATPase inhibitor

CAS:
80890-47-7
Catalog Number:
10-2905
Activity:
V-ATPase inhibitor
Alternate Name:
Folimycin
Molecular Weight:
866.09
Molecular Formula:
C46H75NO14
Solubility:
Soluble in DMSO
Physical Properties:
White solid or lyophilized solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Concanamycin A (80890-47-7) is a potent and specific inhibitor of the vacuolar (V-type) H+-ATPase which can induce apoptotic cell death in various cell lines.1,2 Inhibits cell surface expression of virus envelope glycoproteins.3 Dramatically increases the rate of extracellular vesicle release from a variety of cell types.4 Inhibits autophagy by blocking lysosomal acidification.5

References/Citations:

1) Nishihara et al. (1995), Specific inhibitors if vacuolar type H(+)-ATPases induce apoptotic cell death; Biochem. Biophys, Res. Commun., 212 255
2) Hong et al. (2006), Nitric oxide production by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells; J. Pharmacol. Exp. Ther., 319 672
3) Muroi et al. (1993), Folimycin (concanamycin A), a specific inhibitor of V-ATPase, blocks intracellular translocation of the glycoprotein of vesicular stomatitis virus before arrival to the Golgi apparatus; Cell Struct. Function, 18 139
4) Cashikar and Hanson (1987), A cell-based assay for CD63-containing extracellular vesicles; PLoS One, 14 e0220007
5) Gradzka et al. (2018), Inhibitor of apoptosis proteins are required for effective fusion of autophagosomes with lysosomes; Cell Death Dis., 9 529

Concanamycin A | V-ATPase inhibitor is also available in the Cellular Metabolism Library.
CAS:
80890-47-7
Catalog Number:
10-2905
Activity:
V-ATPase inhibitor
Alternate Name:
Folimycin
Molecular Weight:
866.09
Molecular Formula:
C46H75NO14
Solubility:
Soluble in DMSO
Physical Properties:
White solid or lyophilized solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Add to Quote

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee