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Inhibitors

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  • Focus Biomolecules cell signaling supplier, chemical structure of 3-Methyladenine | Autophagosome inhibitor | CAS 5142-23-4
    $30.00
    3-Methyladenine (5142-23-4) inhibits autophagy by blocking autophagosome formation via inhibition of type III phosphatidylinositol 3-kinases (PI-3K)1,2. Protects 1321N1 astrocytoma cells against pyocyanin and...

  • Focus Biomolecules supplier, chemical structure of Antipain 2HCl | Serine, cysteine protease inhibitor | CAS 37682-72-7
    $35.00
    Antipain 2HCl (CAS 37682-72-7) is a serine/cysteine protease inhibitor. Also inhibits some trypsin-like proteases.1 May be used as an additive to prevent proteolytic activity during recombinant protein production in Sf-9...

  • Focus Biomolecules reagent supplier, chemical structure of Bafilomycin A1 | Vacuolar H+ ATPase inhibitor | CAS 88899-55-2
    $80.00
    Bafilomycin A1 (88899-55-2) is a macrolide antibiotic derived from Streptomyces griseus that is a potent and selective inhibitor of vacuolar H+-ATPases (IC50 = 0.6 – 1.5 nM).1,2 Bafilomycin A1 inhibits autophagy via...

  • Focus Biomolecules supplier, chemical structure of Chloroquine phosphate | autophagy inhibitor | CAS 50-63-5
    $25.00
    Chloroquine phosphate (50-63-5) is an antimalarial drug. Inhibits autophagy in a variety of cell lines1. Induces cell death in breast cancer cell lines and displays antitumor and antimetastatic activity in mouse models of...

  • Daunorubicin HCl | DNA Damaging Agent / Anticancer Agent
    $60.00
    Antitumor antibiotic used in the treatment of acute myeloid leukemias.1 Induces DNA damage by intercalation.2 Induces apoptosis in a variety of cell lines.3 Inhibition of autophagy with chloroquine enhances...

  • Focus Biomolecules supplier, chemical structure of Hydroxychloroquine sulfate | Autophagy inhibitor | CAS 747-36-4
    $30.00
    Hydroxychloroquine sulfate (747-36-4) is a lysosomotropic agent which inhibits autophagy and triggers apoptosis in a variety of cell types.1,2 Augments the anticancer activity of DNA-damaging chemotherapy...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of ISO-1 | MIF antagonist | CAS 478336-92-4
    $105.00
    ISO-1 (478336-92-4) is an antagonist of macrophage migration inhibitory factor (MIF, a pro-inflammatory cytokine). Displays anti-inflammatory activity. Increases survival in severe sepsis1. Inhibits airway remodeling in...

  • Focus Biomolecules supplier, chemical structure of Manzamine A | Inhibitor of vacuolar ATPases | CAS 104196-68-1
    $185.00
    Manzamine A (104196-68-1) inhibits vacuolar ATPases and inhibits autophagy in pancreatic cancer cells1. Suppresses atherosclerosis in vivo2. Manzamine A displays neuritogenic activity3 and suppresses tau...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of MHY1485 | mTOR activator | CAS 326914-06-1
    $44.00
    MHY1485 (326914-06-1) is an mTOR activator. Suppresses autophagy by inhibiting the fusion of autophagosomes with lysosomes leading to the accumulation of enlarged autophagosomes.1 Increases ovarian follicle development.2...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of SBI-0206965 | ULK1 inhibitor | CAS 1884220-36-3
    $65.00
    SBI-0206965 (1884220-36-3) is a potent and selective inhibitor of the autophagy kinase ULK-1, IC50=108 and 711 nM for ULK1 and 2 respectively.1 Suppresses autophagy induced by mTOR inhibitors and thus synergizes with mTOR...

  • Focus Biomolecules supplier, structure of Spautin-1 | Inhibits autophagy by inhibiting USP 10 & 13 | CAS 1262888-28-7
    $70.00
    Spautin-1 (1262888-28-7) is a specific and potent autophagy inhibitor. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific proteases USP10 and USP13 which target the Beclin-1...

  • Focus Biomolecules supplier, chemical structure of Vinblastine sulfate | Microtubule depolymerizer | CAS 143-67-9
    $48.00
    Vinblastine sulfate (143-67-9) is a semisynthetic alkaloidal anticancer agent. Induces cell cycle arrest at G2/M phase by inhibiting mitotic spindle formation.1 Inhibits normal microtubule assembly and induces aberrant...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Wortmannin | PI3K inhibitor | CAS 19545-26-7
    $35.00
    Wortmannin (19545-26-7) is a potent and selective inhibitor of PI3-kinase which acts via covalent modification of Lys-802.2 Inhibits autophagy in rat hepatocytes.3 Inhibits adipocyte differentiation of 3T3-L1 cells...

  • Focus Biomolecules cell signaling reagent supplier, structure of Xanthohumol | VCP / Autophagy inhibitor | CAS 6754-58-1
    $140.00
    Xanthohumol (6754-58-1) binds to the N-terminal domain of valosin-containing protein (VCP), an essential protein for autophagosome maturation. Xanthohumol inhibits the function of VCP thereby impairing autophagosome...

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