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  • ANA-12 | TrkB antagonist
    ANA-12 (219755-25-3) is a TrkB receptor antagonist. Binds to two distinct receptor sites preventing activation by BDNF non-competitively, IC50 = 45.6 nM and 41.1 μM for the high and low affinity sites respectively...

  • C8-Ceramide | Protein kinase activator
    C8-ceramide (74713-59-0) is a cell permeable ceramide analog. Stimulates ceramide-activated protein kinase.1 Induces apoptosis.2 Reported to inhibit apoptosis and gap junction intercellular communication (GJIC) in rat liver...

  • Deltamethrin | Calcineurin inhibitor; displays neurotrophic activity
    Deltamethrin (52918-63-5) is reported to be an inhibitor of calcineurin (PP2B), IC50~100 pM1 but this activity has been disputed2. Markedly enhances the expression of BDNF in cultured rat cortical neurons and displays...

  • Focus Biomolecules supplier, chemical structure of LM22A-4 | TrkB small molecule agonist | CAS 37988-18-4
    LM22A-4 (37988-18-4) is a small molecule BDNF mimetic displaying neurotrophhic activity. Partial agonist at TRKB and activates TRKB signaling. In in vitro models of neurodegenerative disease, it prevented neuronal...

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