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Bioactive Lipids

Bioactive lipids are a diverse group of endogenous molecules that are involved in a wide array of biological processes. Members of this family include prostaglandins, leukotrienes, sphingolipids, fatty acids and their metabolic products, steroids, phospholipids, vitamins, endocannabinoids, and acylglycerol derivatives.

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Sphingolipids

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Fatty acids

  • Erucamide

    Endogenous fatty acid amide with antidepressant and antianxiety effects

  • Oleoylethanolamide

    Endogenous anandamide-like lipid that acts as a GPR119 agonist

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Eicosanoids

  • Anandamide

    Anandamide is an endogenous cannabinoid receptor agonist

  • Prostaglandin A1

    PGA1 is a naturally occurring prostaglandin with diverse biological actions

  • Prostaglandin E2

    PGE2 is a naturally occurring prostaglandin with diverse biological actions

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Lipid biosynthesis inhibitors

  • Cerulenin

    Cerulenin inhibits fatty acid synthase by binding to b-keto-acyl-ACP synthase

  • Fatostatin

    Fatostatin blocks fat synthesis by inhibiting the activation of SREBP

  • Hymeglusin

    Hymeglusin is an inhibitor of HMG-CoA synthase

  • Myriocin

    Blocks sphingolipid biosynthesis via inhibition of serine palmitoyltransferase

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Lipid metabolism inhibitors

  • JZL-184

    JZL-184 is an inhibitor of MAG lipase

  • JNJ-1661010

    JNJ-1661010 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor

  • RHC-80267

    RHC-80267 is a DAG lipase inhibitor

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Cholesterol derivatives

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Lipid receptor agonists and antagonists

  • Grapiprant

    Potent and selective EP4 receptor antagonist

  • AH-7614

    AH-7614 is a selective free fatty acid receptor (FFA4) inhibitor

  • GRI-977143

    GRI-977143 is a selective agonist of the lysophosphatidic acid 2 receptor (LPA2)

  • WEB-2086

    WEB-2086 is a potent and selective antagonist of the platelet activating factor (PAF) receptor

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Lipid phosphates

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