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Bioactive Lipids

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  • 1-Aminobenzotriazole | Cytochrome P450 inhibitor
    1-Aminobenzotriazole | Cytochrome P450 inhibitor
    $50.00
    1-Aminobenztriazole (1614-12-6) is a pan-specific cytochrome P450 inhibitor acting as a suicide substrate.1,2 Blocks omega-oxidation of arachidonic acid but not its epoxidation.3  References/Citations 1) Mugford et al...

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  • 2-Bromopalmitic acid | Palmitoylation inhibitor
    2-Bromopalmitic acid | Palmitoylation inhibitor
    $40.00
    2-Bromopalmitic acid (18263-25-7) inhibits protein S-palmitoylation.1 Blocks palmitic acid-induced increase in cAMP levels in human primary melanocytes expressing the melanocortin-1 receptor which undergoes an essential...

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  • Focus Biomolecules cell signaling reagent supplier, structure of AH-6809 | Prostanoid EP antagonist | CAS 33458-93-4
    AH-6809 | Prostanoid EP antagonist
    $60.00
    AH-6809 (33458-93-4) is a selective PGE2 receptor (EP1) antagonist. At concentrations higher than 10 μM PGD2 and TXA2 receptors are also blocked. References/Citations1) Coleman in Prostaglandins and Related Substances: A...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AH-7614 | GPR120 antagonist | CAS 6326-06-3
    AH-7614 | GPR120 antagonist
    $45.00
    AH-7614 (6326-06-3) is a selective antagonist at free fatty acid receptor 4 (FFA4), also known as GPR120. pIC50s= 7.1 and 1. References/Citations1) Sparks et al. (2014), Identification of diarylsulfonamides as agonists of...

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  • Focus Biomolecules supplier, chemical structure of Anandamide | Endogenous cannabinoid | CAS 94421-68-8
    Anandamide | Endogenous cannabinoid
    $35.00
    Anandamide (94421-68-8) is an endogenous cannabinoid receptor agonist.1-3 Ki=89 nM for CB1 and 371 nM for CB2 receptors. References/Citations1) Devane et al. (1992), Isolation and structure of a brain constituent that binds...

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  • Focus Biomolecules reagent supplier, chemical structure of Baicalein | Protein tyrosine kinase inhibitor | CAS 491-67-8
    Baicalein | Inhibitor of protein tyrosine kinase in leukemia (CEM cells)
    $40.00
    Baicalein (491-67-8) is an inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis1. Originally reported as a selective inhibitor of 12-lipoxygenase, baicalein has since been...

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  • BML-111 | LXA agonist, antiinflammatory
    BML-111 | LXA agonist, antiinflammatory
    $50.00
    BML-111 (78606-80-1) novel truncated analog of lipoxin A4 which retains anti-inflammatory activity.1 Inhibits LTB4-induced leukocyte chemotaxis, IC50=5 nM).1 Attenuates hemorrhagic shock-induced acute lung injury in a rat...

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  • BMS-303141 | ATP citrate lyase (ACL) inhibitor
    BMS-303141 | ATP citrate lyase (ACL) inhibitor
    $70.00
    BMS-303141 (943963-47-8) is a potent and selective ATP citrate lyase (ACL) inhibitor, IC50=0.13 μM. Inhibits lipid biosynthesis, IC50=8 μM in HepG2 cells.1,2 Reduces weight gain, lowers plasma cholesterol,...

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  • Focus Biomolecules cell signaling reagent supplier, structure of C2Ceramide | Cell permeable ceramide | CAS 3102-57-6
    C2 Ceramide | Cell permeable ceramide
    $40.00
    C2 Ceramide (3102-57-6) is a cell permeable ceramide analog. Induces apoptosis in a variety of cell types. Stimulates ceramide-activated protein phosphatases. Activates ceramide-activated protein kinases...

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  • C2-Dihydroceramide | Autophagy inducer
    $50.00
    C2 Dihydroceramide (13031-64-6) is a negative control for C2-ceramide (cat.# 10-1181).1,2 Induces autophagy ina variety of cell types.3,4 References/Citations1) Bielawska et al. (1993) Selectivity of ceramide-mediated...

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  • C22 Ceramide | Structure | supplier
    C22 Ceramide | MCSR inhibitor
    $55.00
    C22 Ceramide is a  long-chain ceramide containing behenic acid. Mitochondrial-to-cytosolic stress response (MCSR) is a recently identified stress response which can be induced by increased synthesis of fatty acids...

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  • Focus Biomolecules cell signaling supplier, chemical structure of C8-Ceramide | Protein kinase activator | CAS 74713-59-0
    C8-Ceramide | Protein kinase activator
    $40.00
    C8-ceramide (74713-59-0) is a cell permeable ceramide analog. Stimulates ceramide-activated protein kinase.1 Induces apoptosis.2 Reported to inhibit apoptosis and gap junction intercellular communication (GJIC) in rat liver...

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  • Focus Biomolecules supplier, chemical structure of Cerulenin | Fatty Acid Synthase inhibitor | CAS 17397-89-6
    Cerulenin | Fatty Acid Synthase inhibitor
    $90.00
    Cerulenin (17397-89-6) is a fatty acid synthase (FAS) inhibitor. Binds to β-keto-acyl-ACP synthase (KAS; IC50=1.5 μM), thus inhibiting protein acylation at concentrations of 45-134 μM.1 Cerulenin produces...

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  • Focus Biomolecules signaling reagents supplier, chemical structure of DCH-Gly | Endogenous lipo-amino acid | CAS 132850-40-9
    DCHA-Gly | Endogenous lipo-amino acid
    $50.00
    DCHA-Gly is an endogenous lipoamino acid.

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  • Focus Biomolecules supplier, chemical structure of Dihydrosphingosine | PKC inhibitor, Sphingosine precursor | CAS 764-22-7
    Dihydrosphingosine | PKC inhibitor, Sphingosine precursor
    $30.00
    Dihydrosphingosine (764-22-7) is a biosynthetic precursor of sphingosine. Inhibitor of protein kinase C1 and phospholipases A2 and D2. References/Citations1) Merrill et al. (1989), Structural requirements for long-chain...

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  • Focus Biomolecules cell signaling reagent supplier, structure of EPA free acid | omega-3 fatty acid | CAS 10417-94-4
    EPA free acid | omega-3 fatty acid
    $30.00
    EPA free acid (10417-94-4) dietary enrichment may have anti-inflammatory effects by inhibiting the 5-lipoxygenase pathway and LTB4-mediated neutrophil functions.1 Displays various cardiovascular protective properties.2...

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  • Focus Biomolecules supplier, chemical structure of Epoxomicin | Irreversible 20S proteasome inhibitor | CAS 134381-21-8
    Epoxomicin | Irreversible 20S proteasome inhibitor
    $145.00
    Epoxomicin (134381-21-8) is a potent, selective and cell permeable irreversible inhibitor of the 20S proteasome.1 It does not inhibit non-proteasomal proteases such as papain, chymotrypsin, trypsin, calpain and cathepsin B...

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  • Erucamide | Antidepressant/Anti-anxiety
    Erucamide | Antidepressant/Anti-anxiety
    $25.00
    Erucamide (112-84-5) is an endogenous fatty acid amide.  It was able to ameliorate depression and anxiety-like behaviors in several mouse models.  Significantly lowered levels of circulating adrenocorticotrophic...

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  • Ezetimibe | Cholesterol absorption inhibitor
    Ezetimibe | Cholesterol absorption inhibitor
    $45.00
    Ezetimibe (163222-33-1) inhibits cholesterol absorption in the intestine by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter.1 Undergoes rapid glucuronidation in the...

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  • Fasnall HCl | Structure | Supplier
    Fasnall HCl | Fatty acid synthase inhibitor
    $64.00
    A potent and selective fatty acid synthase (FASN) inhibitor acting via interfering with cofactor binding.1 IC50s = 147 and 213 nM respectively for inhibition of acetate and glucose incorporation into total lipids in...

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