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Filipin III | Cholesterol probe

CAS:
480-49-9
Catalog Number:
10-1490
Activity:
Cholesterol probe
Source:
Isolated from Streptomyces filipinensis
Molecular Weight:
654.85
Molecular Formula:
C35H58O11
Solubility:
Soluble in Methanol (up to 10 mg/ml)
Physical Properties:
White or light yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in methanol may be stored under inert gas at -20°C for up to 2 months.
Shipping Code:
RT

Filipin III (480-49-9) is a polyene macrolide antibiotic. It may be used in a double staining procedure for the detection of lipoproteins.1 Binds specifically to cholesterol forming a fluorescent complex which may be used for staining.2 Disrupts the lipid raft/caveolae endocytosis pathway.3 Prevents pathological prion protein accumulation by reducing endocytosis and inducing cellular PrP release.4

References/Citations:

1) Smejkal and Hof (1994), Cholesterol-specific probe for lipoproteins immobilized on nitrocellulose membranes; Biotechniques, 16 68
2) Bornig and Geyer  (1974), Staining of cholesterol with the fluorescent antibiotic “filipin”; Acta Histochemica, 50 110
3) Huo et al. (2003), Lipid rafts/caveolae are essential for insulin-like growth factor-1 receptor signaling during 3T3-L1 preadipocyte differentiation induction; J. Biol. Chem., 278 11561
4) Marella et al. (2002), Filipin prevents pathological prion protein accumulation by reducing endocytosis and inducing cellular PrP release; J. Biol. Chem., 277 25457

Filipin III | Cholesterol probe is also available in the Cellular Metabolism Library.
CAS:
480-49-9
Catalog Number:
10-1490
Activity:
Cholesterol probe
Source:
Isolated from Streptomyces filipinensis
Molecular Weight:
654.85
Molecular Formula:
C35H58O11
Solubility:
Soluble in Methanol (up to 10 mg/ml)
Physical Properties:
White or light yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in methanol may be stored under inert gas at -20°C for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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