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Lipid biosynthesis inhibitors

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  • A-769662 is a potent and reversible AMP-activated protein kinase (AMPK) allosteric activator
    A-769662 (844499-71-4) is a potent and reversible AMP-activated protein kinase (AMPK) allosteric activator.  Activates AMPK by binding to the β and γ subunits and not the AMP binding site.1 EC50=0.8 mM for...

  • AK-7 | 420831-40-9 | Structure | Supplier
    AK-7 (420831-40-9) is a selective Sirt2 inhibitor (IC50=15.5 μM) which does not inhibit Sirt1 or Sirt3.1 It down regulates cholesterol biosynthesis genes in primary striatal neurons.1 AK-7 displays...

  • Bestatin HCl | 65391-42-6 | Structure | Supplier
    Bestatin HCl (65391-42-6) inhibits leucine aminopeptidase and aminopeptidases B and N. Inhibits leukotriene A4 hydrolase. Displays immunostimulant activity via activation of macrophages and T lymphocytes. Displays antitumor...

  • Cerulenin | Fatty Acid Synthase inhibitor
    Cerulenin (17397-89-6) is a fatty acid synthase (FAS) inhibitor. Binds to β-keto-acyl-ACP synthase (KAS; IC50=1.5 μM), thus inhibiting protein acylation at concentrations of 45-134 μM.1 Cerulenin produces...

  • Fasnall HCl | Structure | Supplier
    A potent and selective fatty acid synthase (FASN) inhibitor acting via interfering with cofactor binding.1 IC50s = 147 and 213 nM respectively for inhibition of acetate and glucose incorporation into total lipids in...

  • Fatostatin | 125256-00-0 | Structure | Supplier
    Fatostatin (125256-00-0) blocks adipogenesis by inhibiting the activation of SREBP. Inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP). Fatostatin prevents increases in body weight,...

  • Fluvastatin Na | HMG CoA reductase inhibitor
    Potent inhibitor of HMG-CoA reductase, IC50=40-100 nM.1  Clinically useful, orally active antihypercholesterolemic agent. Inhibits vascular smooth muscle proliferation, IC50=70 nM.2 Displays antineuroinflammatory...

  • Fumonisin B1 | Blocks sphingolipid biosynthesis
    Fumonisin B1 (116355-83-0) inhibits ceramide synthesis (sphinganine N-acyltransferase), IC50 = 100 nM. Inhibits de novo sphingolipid biosynthesis (IC50 = 0.7 μM) thereby blocking glycosphingolipid production...

  • Hinokitiol | Iron Chelator antioxidant
    Hinokitiol (499-44-5) is a potent metal chelator that induces differentiation and apoptosis in teratocarcinoma F9 cells.1 It acts as a reversible inhibitor of platelet-type 12-lipoxygenase (IC50 = 100 nM).2 Hinokitiol is...

  • Hymeglusin | Melvalonate biosynthesis inhibitor
    Hymeglusin (29066-42-0) is a inhibitor of eukaryotic mevalonate biosynthesis via inhibition of HMG-CoA synthase, IC50=0.12 mM.1 Acts via covalent modification of the active site Cys129.1,2 Inhibits cholesterol biosynthesis...

  • Lovastatin | 75330-75-5 | Structure | Supplier
    Lovastatin (75330-75-5) Blocks cholesterol and isoprenoid biosynthesis via inhibition of HMG-CoA reductase (Ki=1nM for acid form).1,2 Induces apoptosis in various cell lines.3 Causes cell cycle arrest in early G1 phase.4...

  • Metyrapone | 54-36-4 | Structure | Su[[;ier
    Metyrapone (54-36-4) inhibits cytochrome P450-mediated prostaglandin omega hydroxylation. Inhibits steroid 11β-hydroxylase thereby inhibiting cortisol biosynthesis.

  • MK-886 | 118414-82-1 | Structure | Supplier
    MK-886 (118414-82-7) is an inhibitor of leukotriene biosynthesis(IC50 = 2.5 nM in human PMN)1 via 5-lipoxygenase-activating protein (FLAP) inhibition (IC50 = 30 nM)2. MK-886 also inhibits PPARα (80% inhibition at 10...

  • Myriocin | Blocks sphingolipid biosynthesis
    Myriocin (35891-70-4) is a fungal metabolite with potent immunosuppressant activity.1 It inhibits serine palmitoyltransferase (Ki = 0.28 nM) blocking the synthesis of ceramide.2 Myriocin was found to suppress melanoma cell...

  • Ozagrel HCl | Thromboxane synthase inhibitor
    Ozagrel HCl (78712-43-3) is a potent and selective inhibitor of thromboxane (TXA2) synthetase (IC50 = 4 nM)1. Does not inhibit prostacyclin (PGI2) synthase, cyclooxygenase or PGE2 isomerase (IC50 > 1 mM)1. Inhibits...

  • Simvastatin | 79902-63-9 | Structure | Supplier
    Simvastatin (79902-63-9) is a synthetic analog of lovastatin (cat.# 10-1222). Blocks cholesterol and isoprenoid biosynthesis via inhibition of HMG-CoA reductase1,2. Simvastatin induces apoptosis in various cell lines and...

  • Zileutin | 111406-87-2 | Structure | Supplier
    Zileuton (111406-87-2) is a reversible inhibitor (IC50 = 500nM RBL-1 cells, 300nM rat PMNL cells) of 5-Lipoxygenase (5-LO).1 It also inhibited leukotriene B4 biosynthesis (IC50's = 400nM rat PMNL, 400nM human PMNL and 900nM...

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