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Lipid Metabolism Inhibitors

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  • 1-Aminobenzotriazole | Cytochrome P450 inhibitor
    1-Aminobenztriazole (1614-12-6) is a pan-specific cytochrome P450 inhibitor acting as a suicide substrate.1,2 Blocks omega-oxidation of arachidonic acid but not its epoxidation.3  References/Citations 1) Mugford et al...

  • Baicalein | Inhibitor of protein tyrosine kinase in leukemia (CEM cells)
    Baicalein (491-67-8) is an inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis1. Originally reported as a selective inhibitor of 12-lipoxygenase, baicalein has since been...

  • JNJ-1661010 | 681136-29-8 | Structure | Supplier
    JNJ-1661010 (681136-29-8) is a potent and selective FAAH inhibitor. Initially forms a covalent adduct with FAAH but is slowly released, IC50 = 12 nM. 100-fold selectivity for FAAH-1 over FAAH-2. Cell permeable and active in...

  • JZL-184 | 1101854-58-3 | Structure | Supplier
    JZL-184 (1101854-58-3) inhibits MAG lipase (IC50=8 nM) selectively over FAAH. Irreversible. Cell permeable. References/Citations1) Long et al. (2009), Selective blockade of 2-arachidonoylglycerol hydrolysis produces...

  • LY-2183240 | Anandamide uptake inhibitor
    LY-2183240 (874902-19-9) is highly potent inhibitor of cellular anandamide uptake (IC50 = 0.27nM1, 15nM2). LY-2183240 has also been found2,3,4 to be an inhibitor of fatty acid amide hydrolase (FAAH) - IC50 = 14nM4,...

  • Nonylbenzeneboronic acid | FAAH
    A potent and selective inhibitor of fatty acid amide hydrolase (FAAH, the enzyme which hydrolyzes and deactivates anandamide), IC50=9.1 nM1. Also inhibits monoacylglycerol lipase (MAGL, the enzyme which hydrolyzes...

  • Palmitoylethanolamine | 544-31-0 | Structure | Supplier
    Palmitoylethanolamide (544-31-0) is an endogenous cannabinoid. Weak ligand for CB1 (Ki= 23.8 μM) and CB2 (Ki = 13.9 μM) receptors. Inhibits fatty acid amide hydrolase (FAAH) ((IC50 = 5.1 μM). Modulates mast cell...

  • PF-622 | 898235-63-9 | Structure | Supplier
    PF-622 (898235-65-9) is a potent and selective irreversible FAAH inhibitor. Covalently modifies active site-serine (IC50=33 nM). Completely selective for FAAH relative to other mammalian serine hydrolases. Cell...

  • THI | Immunomodulator
    THI (94944-70-4) was identified as a biologically active impurity in caramel food coloring.1 It is a potent inhibitor of sphingosine-1-phosphate (S1P) lyase.2 It disrupts lymphocyte egress from lymphoid tissue by interfering...

  • URB-597 | 546141-08-6 | Structure | Supplier
    URB-597 (546141-08-6) is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor, IC50 = 3-5 nM.1 Produces cannabinoid CB1 and CB2 receptor-mediated analgesia in inflammatory pain states without causing side...

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