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Lipid receptor agonists and antagonists

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  • Focus Biomolecules cell signaling reagent supplier, structure of AH-6809 | Prostanoid EP antagonist | CAS 33458-93-4
    AH-6809 (33458-93-4) is a selective PGE2 receptor (EP1) antagonist. At concentrations higher than 10 μM PGD2 and TXA2 receptors are also blocked. References/Citations1) Coleman in Prostaglandins and Related Substances: A...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AH-7614 | GPR120 antagonist | CAS 6326-06-3
    AH-7614 (6326-06-3) is a selective antagonist at free fatty acid receptor 4 (FFA4), also known as GPR120. pIC50s= 7.1 and 1. References/Citations1) Sparks et al. (2014), Identification of diarylsulfonamides as agonists of...

  • CYM-5541 | Allosteric sphingosine-1-phosphate receptor 3 agonist
    CYM-5541 (945128-26-7) is a potent and selective allosteric agonist of the sphingosine-1-phosphate receptor 3 (S1P3; EC50’s = 72.3-132 nM).1,2 References/Citations1) Guerrero et al. (2011), Probe Development Efforts...

  • Grapiprant | EP4 Receptor antagonist
    Grapiprant (415903-37-6) is a potent (Ki = 13 nM for human and 20 nM for rat) and selective prostaglandin EP4 receptor antagonist.1 It produces antihyperalgesic effects in animal models of pain, and has significant...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of GRI-977143 | LPA2 antagonist | CAS 325850-80-5
    GRI-977143 (325850-81-5) is a selective agonist of the lysophosphatidic acid-2 (LPA2) receptor. Displays antiapoptotic activity.1 Rescues apoptotically condemned cells from death and injury caused by high-dose...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of H2L5186303 | LPA2 antagonist | CAS 139262-76-3
    H2L5186303 (139262-76-3) is a potent and selective lysophosphatidic acid 2 (LPA2) receptor antagonist.  IC50 = 8.9 nM, 1230 nM and 27.35 μM for LPA2, LPA3, and LPA1 respectively.1,2 References/Citations 1) Fells et...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure LY-171883 | Cys LT1 antagonist | CAS 88107-10-2
    LY-171883 (88107-10-2) is a selective and orally active leukotriene D4 (LTD4) antagonist (Ki = 0.63 μM).1 It is also an activator of peroxisome proliferator-activated receptors (PPAR's).2,3 References/Citations1) Fleisch...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of MK-571 | Cys LT1 antagonist | CAS 115104-28-4
    MK-571 (115104-28-4) is a potent (EC50 = 1.3nM) and selective Leukotriene D4 antagonist (LTD4)1 displaying inverse agonist activity2. Blocks binding of LTD4 to human (Ki = 0.22 nM) and guinea pig (Ki = 2.1 nM) lung membranes...

  • N-Arachidonoyldopamine | Endogenous TRPV1 activator
    N-Arachidonoyldopamine (199875-69-9) is an endogenous conjugate of arachidonic acid and dopamine.1 May be the “endogenous capsaicin like substance” in the CNS acting at TRPV1 channels, EC50~ 50 nM1. Also acts as...

  • Focus Biomolecules supplier, chemical structure of WEB-2086 | PAF receptor antagonist | CAS 105219-56-5
    WEB-2086 (105219-56-5) is a potent and selective antagonist of the platelet activating factor (PAF) receptor (Ki = 16.3 nM).1 Displays an activity profile which includes antiinflammatory, antiangiogenesis and anticancer...

  • Focus Biomolecules offers cell signaling reagent, Zafirlukast | HSP70 inhibitor, leukotriene antagonist | CAS 107753-78-6
    Zafirlukast (107753-78-6) is a competitive and selective leukotriene receptor antagonist1. Also inhibits calcium ionophore induced production of leukotriene B4 and leukotriene C4, which suggests a potential 5-LO inhibitory...

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