Simvastatin | HMG-CoA reductase inhibitor

Simvastatin (79902-63-9) is a synthetic analog of lovastatin (cat.# 10-1222). Blocks cholesterol and isoprenoid biosynthesis via inhibition of HMG-CoA reductase^1,2. Simvastatin induces apoptosis in various cell lines and causes cell cycle arrest in early G₁ phase. Clinically useful antilipemic agent³.

References/Citations
1) Merck 14:8539
2) Hancock et al. (1989), All ras proteins are polyisoprenylated but only some are palmitoylated; Cell, 57 1167
3) Ose et al. (2000), Lipid-altering efficacy and safety of simvastatin 80 mg/day: long-term experience in a large group of patients with hypercholesterolemia. World Wide Expanded Dose Simvastatin Study Group Clin. Cardiol. 23 39
4) Matsuzaka et al. (2016) Characterization and functional analysis of extracellular vesicles and muscle-abundant miRNA in C2C12 myocytes and Mdx mice; PLoS One 11(12) e0167811 [Focus Biomolecules Citation]

Weight	0.01 mg
Dimensions	0.01 × 0.01 × 0.01 cm
Size:	100 mg, 500 mg

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CAS:

79902-63-9

Catalog Number:

10-1018

Activity:

HMG-CoA reductase inhibitor

Alternate Names:

Mevinolin

Chemical Name:

2,2-Dimethyl-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester butanoic acid

Molecular Weight:

418.58

Molecular Formula:

C₂₅H₃₈O₅

Solubility:

Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 35 mg/ml).

Physical Properties:

White solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

Shipping Code:

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Product Data Sheet

Simvastatin-supplier__08226.1549428124.356.300

Simvastatin | HMG-CoA reductase inhibitor

Name: Simvastatin | HMG-CoA reductase inhibitor
SKU: 10-1018
Availability: InStock

$50.00 – $165.00

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SKU: 10-1018 Categories: Apoptosis, Approved Drugs, Bioactive Lipids, Biosynthesis inhibitors, Cardiovascular, Cell Cycle, Cell Death, Cholesterol, Inhibitors, Lipid biosynthesis inhibitors, Lipid Metabolism, Other Bioactive Lipids Tags: 79902-63-9, Simvastatin, Supplier

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Simvastatin | HMG-CoA reductase inhibitor