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Bioinorganic Chemistry

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  • 1,10-Phenanthroline HCl | Zn metalloprotease inhibitor
    1,10-Phenanthroline (18851-33-7) is a high affinity chelator of divalent metal ions and may be used to inhibit zinc metalloenzymes.1  It is a potent inhibitor of JAMM-type isopeptidases (DUBs) acting via chelation of an...

  • Bleomycin sulfate | Induces double strand DNA breaks
    Bleomycin sulfate (9041-93-4) co ordinates with metals producing reactive oxygen species which causes oxidative damage to DNA1 and RNA2. Induces double-strand DNA damage3. Commonly used to induce lung fibrosis in animal...

  • TPEN | 168858-02-9 | Structure | Supplier
    TPEN (16858-02-9) is a cell permeable metal chelator. Frequently used to study effects of zinc depletion on cellular processes.1,2 References/Citations1) Chimienti et al. (2001) Role of cellular zinc in programmed cell...

  • U-74389G | Free radical scavenger
    U-74389G (153190-29-5) is an antioxidant and Inhibits iron-mediated lipid peroxidation.1 It has also been shown to reduce free radical-mediated injury after ischemia and reperfusion.2,3 References/Citations1) Braughler et...

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