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Bioinorganic Chemistry

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  • Focus Biomolecules supplier, chemical structure of 1,10-Phenanthroline HCl | Zn metalloprotease inhibitor | CAS 18851-33-7
    1,10-Phenanthroline (18851-33-7) is a high affinity chelator of divalent metal ions and may be used to inhibit zinc metalloenzymes.1  It is a potent inhibitor of JAMM-type isopeptidases (DUBs) acting via chelation of an...

  • Focus Biomolecules supplier, chemical structure of Bleomycin sulfate | Induces double strand DNA breaks | CAS 9041-93-4
    Bleomycin sulfate (9041-93-4) coordinates with metals producing reactive oxygen species which causes oxidative damage to DNA1 and RNA2. Induces double-strand DNA damage.3 Commonly used to induce lung fibrosis in animal...

  • Deferiprone | Iron Chelator
    Deferiprone (30652-11-0) is a clinically useful iron chelator.1 It attenuated blood-brain-barrier breakdown and brain mitochondrial dysfunction in rats with chronic iron-overload.2 Iron chelation therapy has been suggested...

  • Divin | Divisome assembly inhibitor
    Divin is an iron, cobalt, and copper chelator that arrests the late stages of cytokinesis in bacteria by blocking the physical process of constriction in dividing cells without affecting FtsZ. Iron starvation leads to...

  • Dp44mT | Metal chelator
    Dp44mT (152095-12-0) is a metal chelator with potent antitumor activity.1,2 It displayed an average IC50 of 30 nM over 28 cancer cell lines (IC50 range was 5 nM to 400 nM).2 Dp44mT retained its antiproliferative activity in...

  • Eltrombopag | Small molecule thrombopoietin agonist
    Eltrombopag (496775-61-2) is a novel, orally active, small molecule human thrombopoietin receptor (TPO-R) agonist, EC50=0.27 μM.1,2 Maintains human hematopoietic stem and progenitor cells under inflammatory conditions.3...

  • Focus Biomolecules cell signaling reagent supplier, structure of TPEN | Intracellular Zn2+ chelator | CAS 168858-02-9
    TPEN (16858-02-9) is a cell permeable metal chelator. Frequently used to study effects of zinc depletion on cellular processes.1,2 References/Citations1) Chimienti et al. (2001) Role of cellular zinc in programmed cell...

  • Focus Biomolecules cell signaling reagent supplier, structure of U-74389G | Free radical scavenger | CAS 153190-29-5
    U-74389G (153190-29-5) is an antioxidant and Inhibits iron-mediated lipid peroxidation.1 It has also been shown to reduce free radical-mediated injury after ischemia and reperfusion.2,3 References/Citations1) Braughler et...

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