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Bioinorganic Chemistry

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  • 1,10-Phenanthroline HCl | Zn metalloprotease inhibitor
    1,10-Phenanthroline (18851-33-7) is a high affinity chelator of divalent metal ions and may be used to inhibit zinc metalloenzymes.1  It is a potent inhibitor of JAMM-type isopeptidases (DUBs) acting via chelation of an...

  • Bleomycin sulfate | Induces double strand DNA breaks
    Bleomycin sulfate (9041-93-4) co ordinates with metals producing reactive oxygen species which causes oxidative damage to DNA1 and RNA2. Induces double-strand DNA damage3. Commonly used to induce lung fibrosis in animal...

  • Divin | Divisome assembly inhibitor
    Divin is an iron, cobalt, and copper chelator that arrests the late stages of cytokinesis in bacteria by blocking the physical process of constriction in dividing cells without affecting FtsZ. Iron starvation leads to...

  • Focus Biomolecules cell signaling reagent supplier, structure of TPEN | Intracellular Zn2+ chelator | CAS 168858-02-9
    TPEN (16858-02-9) is a cell permeable metal chelator. Frequently used to study effects of zinc depletion on cellular processes.1,2 References/Citations1) Chimienti et al. (2001) Role of cellular zinc in programmed cell...

  • Focus Biomolecules cell signaling reagent supplier, structure of U-74389G | Free radical scavenger | CAS 153190-29-5
    U-74389G (153190-29-5) is an antioxidant and Inhibits iron-mediated lipid peroxidation.1 It has also been shown to reduce free radical-mediated injury after ischemia and reperfusion.2,3 References/Citations1) Braughler et al...

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