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Calcium Signaling

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  • Amlodipine | 88150-42-9 | Structure | Supplier
    Amlodipine (88150-42-9) is an anti-hypertensive L-type calcium channel blocker, which also benefits the cardiovascular system by stimulating nitric oxide synthase, inhibiting angiotension-induced oxidative stress and...

  • Antibiotic A-23187 | Ca2+ ionophore
    Antibiotic A-23187 (52665-69-7) is a highly selective divalent cation ionophore, commonly used to increase intracellular Ca2+ levels in intact cells (though it is most selective for Mn2+).1 It uncouples oxidative...

  • Azoramide | UPR modulator
    Azoramide (932986-18-0) is a modulator of the unfolded protein response (UPR).1  It improves endoplasmic reticulum (ER) protein folding and activates ER chaperone capacity to protect cells against ER stress. It...

  • BAPTA-AM | 126150-97-8 | Structure | Supplier
    BAPTA-AM (126150-97-8) is a selective cell permeable Ca2+ chelator. It is a widely used intracellular calcium sponge1,2. Rapidly taken up by cells where it is irreversibly hydrolyzed to BAPTA by intracellular esterases...

  • BAPTA-free acid | Extracellular calcium sponge
    BAPTA (85233-19-8) is a selective extracellular Ca2+ chelator. It is a widely used calcium sponge for chelating Ca2+outside of intact cells.1 It’s a useful tool to probe the involvement of extracellular Ca2+ in...

  • BAY K8644 | L-type calcium channel activator
    BAY K8644 (71145-03-4) is an L-type Ca2+-channel activator with positive inotropic and vasoconstrictive effects.1-4 References/Citations1) Schramm et al. (1983) Novel Dihydropyridines with positive inotropic action through...

  • Dantrolene Na | SR calcium release inhibitor
    Dantrolene Na (14663-23-1) inhibits release of Ca2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor channels with selectivity for RYR1 and RYR3 over RYR2.1 Protects against quisqualate and NMDA-induced...

  • Diltiazem HCl | 33286-22-5 | Structure | Supplier
    Diltiazem HCl (33286-22-5) is a non-dihydropyridine-type blocker of L-type Ca2+ channels1,2.Reduces Ca2+ oscillations in subcellular compartments in vascular smooth muscle cells3. Also blocks P-type Ca2+ channels in...

  • Felodipine | L-type Ca channel blocker
    Felodipine (72509-76-3) is a potent L-type Ca2+ channel blocker that is selective over N-, R-, P/Q- and T-type channels.1,2 It displays high vascular selectivity over cardiac muscle, thus lowering arterial blood pressure...

  • FLUO-8 (AM) | Structure | supplier
    FLUO-8 (AM) is a cell-permeable acetoxymethyl (AM) ester derivative of Fluo-8. Approximately twice as bright as Fluo-4. Absorbance 452 nm (26,000); Emission 515 nm (after AM hydrolysis; dissolved in 10 mM EGTA, 100 mM KCl,...

  • GBR-12909 2HCl | Dopamine reuptake inhibitor
    GBR-12909 2HCl (67469-78-7) is a potent and selective inhibitor of dopamine reuptake (Ki = 1 nM) with greater than 100 fold selectivity over serotonin and noradrenaline.1 GBR-12909 2HCl also acts as a potent sigma...

  • Ionomycin | Ca2+ ionophore
    Ionomycin (56092-81-0) is a highly selective nonfluorescent calcium (Ca2+) ionophore.1 Induces a rapid rise in cytosolic Ca2+ in human neutrophils which is due to both release from cytosolic Ca2+ stores as well as Ca2+...

  • Isradipine | 75695-93-1 | Structure | Supplier
    Isradipine (75695-93-1) is an L-type calcium channel blocker. Displays antiatherosclerotic effects and improves endothelium-mediated nitric oxide-dependent vasodilation. Isradipine displays neuroprotective activity in rat...

  • KB-R7943 mesylate | 182004-65-5 | Structure | Supplier
    KB-R7943 (182004-65-5) is a potent and selective inhibitor of the reversed Na+/Ca2+ exchanger (NCE or NCX; IC50's = 1.2-2.4 μM in cardiomyocytes, smooth muscle cells, NCX1-transfected fibroblasts1; 0.7 μM in cultured...

  • Lomerizine | Calcium Channel Blocker
    Lomerizine (101477-54-7)is a clinically useful calcium channel blocker (L and T-type).  It is used for the treatment of migraine headaches, however its antimigraine effects are believed to be due to its 5HT2A...

  • m-3M3FBS | Phospholipase C activator
    m-3M3FBS (200933-14-8) is an activator of phospholipase C (PLC). Stimulates superoxide generation, Ca2+ release and inositol phosphate release in a variety of cell types1. Inhibits growth of U937 and THP-1 cells2. m-3M3FBS...

  • N-Acetyl-S-farnesyl-L-cysteine | S-Farnesylcysteine methyl transferase inhibitor
    N-Acetyl-S-farnesyl-L-cysteine (AFC) (135304-07-3) inhibits S-farnesylcysteine methyl transferase (Km = 20 µM).1 AFC blocked capacitative Ca2+ influx in human embryonic kidney 293 cells2 and store-regulated Ca2+ entry...

  • Nicardipine HCl | L-type Ca channel blocker / MDR inhibitor
    Nicardipine (54527-84-3) is a clinically useful L-type calcium blocker. Inhibitor of MDR.2 References/Citations1) Merck 14 6495 2) Hulubei et al. (2012), 4-Isoxazolyl-1,4-dihydropyridines exhibit binding at the...

  • Nifedipine | 21829-25-4 | Structure | Supplier
    Nifedipine (21829-25-4) is a clinically useful L-type calcium blocker. References/Citations1) Vater et al., (1972), (Pharmacology of 4-(2'-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester...

  • Niguldipine HCl | 113317-61-6 | Structure | Supplier
    Niguldipine HCl (113317-61-6) is an L-type calcium channel blocker (IC50 = 75 nM), which can also inhibit T-type calcium channels at higher concentrations (IC50 = 244 nM). Novel inhibitor of drug transport by p-glycoprotein...

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