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Cancer

Cancer is a collection of related genetic diseases that cause cells to divide uncontrollably and spread to surrounding tissues. Phenotypic changes to cancer cells include abnormal shape, fast rate of division, high metabolic rate, and invasion of surrounding tissues. The aberrant genes that lead to cancer can arise from DNA damage caused by environmental sources, errors that occur during cell division, or inherited. Tumor promoting genetic mutations occur in oncogenes that activate pathways related to cell proliferation or inactivate cell death pathways. Mutations in tumor suppressor genes lead to loss of function in growth inhibition, DNA damage repair, and apoptosis activation pathways.

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Cytoskeleton

  • Epothilone B

    Epothilone B induces microtubule polymerization

  • Cytochalasin D

    Cytochalasin D is a potent inhibitor of actin polymerization

  • K858

    K858 is a selective mitotic kinesin Eg5 inhibitor

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Epigenetics

  • I-BET762

    I-BET762 is a potent inhibitor of the BET family of bromodomains

  • SP2509

    SP2509 is a potent and reversible inhibitor of LSD1

  • CPI-455

    CPI-455 is a potent and selective inhibitor of the lysine demethylase KDM5

  • EPZ015666

    Potent and selective inhibitor of the arginine methyltransferase PRMT5

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Kinases

  • R428

    AXL inhibitor that suppresses myeloid cell activation

  • Galunisertib

    TGF-β kinase inhibitor that reverses TGF-β and Treg mediated T cell suppression

  • RO-3306

    RO-3306 is a selective inhibitor of CDK1

  • KU-55933

    KU-55933 is a potent and selective ATM kinase inhibitor

  • NU7441

    DNA protein kinase inhibitor

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Metabolism

  • Koningic acid

    Potent and selective inhibitor of glyceraldehyde-3-phosphate dehydrogenase

  • CB-839

    Potent and selective inhibitor of glutaminase (KGA and GAC)

  • 2-NBD-Glucose

    Fluorescent glucose uptake probe

  • Kifunensine

    Kifunensine Inhibits glycoprotein processing via inhibition of class I α-mannosidases

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DNA Damage / Repair

  • Rucaparib phosphate

    Rucaparib is a potent PARP1 inhibitor

  • RI-1

    RI-1 is a selective inhibitor of RAD51

  • Lomeguatrib

    Lomeguatrib is a potent inhibitor of the DNA methyltransferase MGMT

  • Mirin

    Mirin is an inhibitor of the Mre11-Rad50-Nbs1 complex

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Immunology

  • Epacadostat

    Epacadostat is a potent and selective inhibitor of IDO1

  • CPI-444

    CPI-444 is a potent and selective adenosine A2A antagonist

  • Motolimod

    Selective TLR8 agonist

  • SHP099

    SHP099 is an SHP2 phosphatase inhibitor that mediates PD-1 and CTLA immune checkpoint pathways

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Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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