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Actinomycin D | Transcription inhibitor

CAS:
50-76-0
Catalog Number:
10-2054
Activity:
Transcription inhibitor
Molecular Weight:
1255.42
Molecular Formula:
C62H86N12O16
Solubility:
Soluble in DMSO (50 mg/ml).
Physical Properties:
Orange-red solid
Purity:
>98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Protect from exposure to light and moisture. Solutions are not stable and must be made fresh and used within one working day. Do not store solutions.
Shipping Code:
RT

Actinomycin D (50-76-0) is a cyclopeptide antibiotic and intercalating transcription inhibitor with anti-neoplastic activity. Potent inhibitor of RNA polymerase.1 Induces apoptosis in a variety of cancer cell lines2,3via the intrinsic pathway4.  Upregulates proapoptotic PUMA and downregulates Bcl-2 mRNA in peripheral blood lymphocytes.5

References/Citations:

1) Wagner et al.(2013) RNA Polymerase II acts as an RNA-dependent RNA polymerase to extend and destabilize a non-coding RNA ; EMBO J. 32 781
2) J. Kleeff et al. (2000) Actinomycin D induces apoptosis and inhibits growth of pancreatic cancer cells; Int. J. Cancer, 86 399
3) Kasim et al. (2013) Live fluorescence and transmission-through-dye microscopic study of actinomycin D-induced apoptosis and apoptotic volume decrease ; Apoptosis,18 521
4) Liu et al. (2016) Actinomycin D enhances killing of cancer cells by immunotoxin RG7787 through activation of the extrinsic pathway of apoptosis; Proc. Natl. Acad. Sci. USA, 113 10666
5) Kalousec et al. (2007) Actinomycin D upregulates proapoptotic protein Puma and downregulates Bcl-2 mRNA in normal peripheral blood lymphocytes; Anticancer Drugs, 18 763
6) Matsuzaka et al. (2016) Characterization and functional analysis of extracellular vesicles and muscle-abundant miRNA in C2C12 myocytes and Mdx mice; PLoS One11(12) e0167811 [Focus Biomolecules Citation]

Actinomycin D | Transcription inhibitor is also available in the Cellular Metabolism Library.
CAS:
50-76-0
Catalog Number:
10-2054
Activity:
Transcription inhibitor
Molecular Weight:
1255.42
Molecular Formula:
C62H86N12O16
Solubility:
Soluble in DMSO (50 mg/ml).
Physical Properties:
Orange-red solid
Purity:
>98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Protect from exposure to light and moisture. Solutions are not stable and must be made fresh and used within one working day. Do not store solutions.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

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