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  • Focus Biomolecules, chemical structure Itraconazole | Autophagy inducer / Inhibits glioblastoma growth | CAS 84625-61-6
    Itraconazole (84625-61-6) inhibits the conversion of lanosterol to ergosterol via inhibition of the 14-α demethylase, a cytochrome P-450 enzyme.1 Clinically useful antifungal agent. It inhibits the proliferation of...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Salirasib | Ras inhibitor | CAS 162520-00-5
    Salirasib (162520-00-5) is a synthetic farnesylcysteine mimetic that inhibits ras proteins1,2 via disruption of interactions between the S-Prenyl moiety of Ras and the membrane anchorage domains3.  It has been...

  • Focus Biomolecules supplier, structure of Spautin-1 | Inhibits autophagy by inhibiting USP 10 & 13 | CAS 1262888-28-7
    Spautin-1 (1262888-28-7) is a specific and potent autophagy inhibitor. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific proteases USP10 and USP13 which target the Beclin-1...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of STF-62247 | Autophagy inducer | CAS 315702-99-9
    STF-62247 (315702-99-9) specifically induces autophagic cell death in VHL (von Hippel-Lindau)-deficient renal carcinoma cells both in vitro (IC50=625 nM) and in vivo. Renal cell carcinoma cell lines were radiosensitized by...

  • Focus Biomolecules supplier, chemical structure of Vinblastine sulfate | Microtubule depolymerizer | CAS 143-67-9
    Vinblastine sulfate (143-67-9) is a semisynthetic alkaloidal anticancer agent. Induces cell cycle arrest at G2/M phase by inhibiting mitotic spindle formation.1 Inhibits normal microtubule assembly and induces aberrant...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of YM-155 | Survivin inhibitor | CAS 781661-94-7
    YM-155 (781661-94-7) is a novel small molecule survivin suppressant. YM-155 suppresses expression of survivin (a member of the IAP family) and induced apoptosis in human tumor cell lines at 10 nmol/L with little effect on...

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