PF-543 HCl | Sphingosine kinase-1 inhibitor
PF-543 (1706522-79-3) is a potent (IC50 = 2.0 nM) and selective (>100-fold over SphK2) reversible inhibitor of sphingosine kinase-1 (SphK1).1 It induced autophagy in head and neck squamous
Autophagy
Autophagy is a catabolic process that enables a cell to avoid death by selectively degrading unnecessary or dysfunctional cytosolic components for recycling into energy and essential building blocks. It is employed in response to normal (for example, development) and abnormal (for example, cancer) stresses, which can be either internal (such as protein aggregates or cellular homeostasis) or external (such as nutrient limitation). More recently, autophagy has also been shown to be used as a cell death pathway [autophagic cell death (ACD)], such as in tumor suppression.
Inducers
Oligomycin A | Mitochondrial ATPase inhibitor
CAS:
579-13-5
Catalog Number:
10-5368
Activity:
Mitochondrial ATPase inhibitor
Source:
Streptomyces sp.
Molecular Weight:
791.06
Molecular Formula:
C45H74O11
Solubility:
Soluble in DMSO (up to 300 mg/ml); Ethanol (up to 200 mg/ml)
Physical Properties:
White solid
Purity:
>98% TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
PLX4720 | Mutant B-Raf inhibitor
CAS:
918505-84-7
Catalog Number:
10-5113
Activity:
Mutant B-Raf inhibitor
Chemical Names:
N-[3-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
Molecular Weight:
413.82
Molecular Formula:
C17H14ClF2N3O3S
Solubility:
Soluble in DMSO (30 mg/ml with warming)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Inhibitors
Vacuolin-1 | Autophagy/PIKfyve inhibitor
Vacuolin-1 (351986-85-1) inhibits autophagy via inhibition of Ca2+-dependent fusion of lysosomes with the plasma membrane and the release of lysosomal content and has no effect on
Rotenone | Mitochondrial Complex I Inhibitor
CAS:
83-79-4
Catalog Number:
10-2277
Activity:
Mitochondrial Complex I Inhibitor
Chemical Names:
(2R,6aS,12aS)-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one
Alternate Name:
NSC-26285; Nicouline
Molecular Weight:
394.42
Molecular Formula:
C23H22O6
Solubility:
Soluble in DMSO (50 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
Room Temperature
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Autophinib | Autophagy inhibitor
CAS:
1644443-47-9
Catalog Number:
10-3476
Activity:
Autophagy inhibitor
Chemical Names:
6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-4-pyrimidinamine
Molecular Weight:
346.73
Molecular Formula:
C14H11ClN6O3
Solubility:
Soluble in DMSO (30 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
