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Cellular Stress

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  • (R)-(+)-Etomoxir Na | Carnitine palmitoyltransferase inhibitor
    Etomoxir (828934-41-4) is an irreversible inhibitor of mitochondrial carnitine palmitoyl transferase 1 (CPT1).1 It is widely used to study fatty acid oxidation. Etomoxir has been investigated as a therapeutic agent for heart...

  • Focus Biomolecules reagent supplier, chemical structure of 1,4-DPCA | Prolyl hydroxylase inhibitor | CAS 331830-20-7
    1,4-DPCA (331830-20-7) is a potent inhibitor of prolyl 4-hydroxylase (IC50=2-4 μM)1. Inhibits collagen deposition via inhibition of collagen proline hydroxylation2,3. Subcutaneous injection of a 1,4-DPCA containing...

  • Focus Biomolecules cell signaling tech supplier, structure 5-Fluorouracil | Inhibitor of thymidylate synthase | CAS 51-21-8
    5-Fluorouracil (51-21-8) is a clinically useful anticancer agent that acts via irreversible inhibition of thymidylate synthase. The active metabolites of 5-Fluorouracil are 5-Fluorodeoxyuridylate (5-FdUMP),...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Artesunate | Kills cancer stem cells | CAS 88495-63-0
    Artesunate (88495-63-0) is a semisynthetic derivative of the natural product artemisinin which is clinically useful for treatment of malaria and other parasitic diseases. Depolarizes mitochondrial membrane via generation of...

  • BAY 87-2243 | HIF-1 / Mitochondrial complex I inhibitor
    BAY 87-2243 (1227158-85-1) potently inhibits HIF-1 reporter gene activity (IC50 = 0.7 nM) and CA9 protein expression (IC50 = 2.0 nM).1 It inhibited HIF-1α and HIF-2α protein accumulation in hypoxic H460 cells and...

  • Focus Biomolecules cell signaling reagent supplier, structure of Camptothecin | Topoisomerase I inhibitor | CAS 7689-03-4
    Camptothecin (7689-03-4) is a natural product isolated from the Chinese Happy Tree, Camptotheca acuminate. It is an inhibitor of DNA topoisomerase I. Camptothecin binds irreversibly to the topoisomerase I /DNA complex...

  • Focus Biomolecules supplier, chemical structure of Doxorubicin HCl | DNA damaging agent | CAS 25316-40-9
    Doxorubicin HCl (25316-40-9) is an antitumor antibiotic. Induces DNA damage by intercalation1 and inhibition of topoisomerase II. Doxorubicin HCl induces apoptosis in a variety of cell lines2. Acts as a substrate for MDR13...

  • Dp44mT | Metal chelator
    Dp44mT (152095-12-0) is a metal chelator with potent antitumor activity.1,2 It displayed an average IC50 of 30 nM over 28 cancer cell lines (IC50 range was 5 nM to 400 nM).2 Dp44mT retained its antiproliferative activity in...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Echinomycin | HIF-1alpha inhibitor | CAS 512-64-1
    Echinomycin (CAS 512-64-1) is a potent and selective hypoxia inducible factor 1α (HIF-1α) inhibitor. It binds to DNA via bifunctional intercalation, blocking the interaction of HIF-1α.1 Protects mice...

  • Focus Biomolecules cell signaling supplier, chemical structure of Epirubicin HCl | DNA damaging agent | CAS 56390-09-1
    Epirubicin HCl (56390-09-1) is an antitumor agent.1 Inhibits topoisomerase II.2 Induces DNA damage by a number of different mechanisms including intercalation, free radical-mediated oxidation, crosslinking,...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Everolimus | mTOR inhibitor | CAS 159351-69-6
    Everolimus (159351-69-6) is a semisynthetic analog of rapamycin (Cat.# 10-1104) with potent immunosuppressive activity.1 Inhibits mTOR.2 Everolimus is a clinically useful immunosuppressant.3 References/Citations1)...

  • Focus Biomolecules supplier, chemical structure of Irinotecan HCl | Topoisomerase I inhibitor | CAS 136572-09-3
    Irinotecan (136572-09-3) is a semi-synthetic derivative of camptothecin (Cat.# 10-1041) that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38,...

  • Focus Biomolecules cell signaling tech supplier, structure of Mitomycin C | DNA crosslinking & damaging agent | CAS 50-07-7
    Mitomycin C (50-07-7) is a DNA damaging and crosslinking agent. Induces apoptosis in various cell lines. Cell permeable. This product is not approved for human therapeutic use. References/Citations1) Tee and Proud (2000),...

  • Nelfinavir mesylate | HIV protease inhibitor / Anticancer activity
    Nelfinavir mesylate (159989-65-8) is a clinically useful anti-HIV agent acting via inhibition of HIV-1 protease (Ki=2 nM).1 It also displays efficacy in cancer, malaria, tuberculosis and SARS.2 Displays broad spectrum...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of NSC59984 | p53 activator | CAS 803647-40-7
    NSC59984 (803647-40-7) is a p53 activator.  Restores wild-type p53 signaling and depletes mutant p53 gain of function. Induces mutant p53 protein degradation via MDM2 and ubiquitin-proteasome pathway. Induces...

  • Focus Biomolecules supplier, chemical structure of NVP-BEZ235 | PI 3-K and mTOR inhibitor | CAS 915019-65-7
    NVP-BEZ235 (915019-65-7) is a dual PI3K and mTOR kinase inhibitor.1 It inhibits VEGF-induced proliferation and angiogenesis.2 Reverses lapatinib resistance.3 It induces G1 arrest and reduces cyclin D1...

  • Ophiobolin A | Autophagy inducer / Anticancer
    Ophiobolin A (4611-05-6) selectively inhibits the growth of cancer cells (IC50=0.4-4.3 μM) over normal cells (IC50=20.9 μM).1 Induces non-apoptotic cell death in glioblastoma cells and is active in an in vivo model.2...

  • Focus Biomolecules cell signaling tech supplier, chemical structure of Piperlongumine | Glutathione sponge | CAS 20069-09-4
    Piperlongumine (20069-09-4) elevates cellular levels of reactive oxygen species selectively in cancer cell lines1. Irreversible glutathionylation leading to depletion of cellular glutathione is associated with its cellular...

  • PRIMA-1(MET) | Reactivates mutant p53
    PRIMA-1MET reactivates mutant p53, an important tumor suppressor gene, in cancer cells.1 It induces p53-dependent apoptosis via activation of caspase-2.2 PRIMA-1MET showed significant antitumor activity in multiple myeloma...

  • Quinacrine HCl | Antiprotozoan / Anticancer
    Quinacrine HCl (69-05-6) is an antiprotozoan drug used for malaria and giardiasis and has recently been investigated in treating lupus, as an anticancer agent, inflammation, and as a female sterilization agent.1 It has been...

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