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Chemotherapeutics

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  • Focus Biomolecules cell signaling reagent supplier, structure of 5-Azacytidine | DNA hypomethylation agent | CAS 320-67-2
    $20.00
    5-Azacytidine (320-67-2) is specific inhibitor of DNA methyltransferase1. Incorporates into DNA and covalently reacts with and inhibits DNA methyltransferases. Induces demethylation and reactivation of silenced genes2...

  • Focus Biomolecules cell signaling tech supplier, structure 5-Fluorouracil | Inhibitor of thymidylate synthase | CAS 51-21-8
    $20.00
    5-Fluorouracil (51-21-8) is a clinically useful anticancer agent that acts via irreversible inhibition of thymidylate synthase. The active metabolites of 5-Fluorouracil are 5-Fluorodeoxyuridylate (5-FdUMP),...

  • Acalabrutinib | Highly selective BTK inhibitor
    $45.00
    Acalabrutinib (1420477-60-6) is a highly selective, potent (IC50 = 3nM), and irreversible inhibitor of Bruton’s tyrosine kinase (BTK).1 Improved target selectivity (especially against TEC family kinases and EGFR)...

  • Focus Biomolecules supplier, chemical structure of Actinomycin D | Transcription inhibitor | CAS 50-76-0
    $50.00
    Actinomycin D (50-76-0) is a cyclopeptide antibiotic and intercalating transcription inhibitor with anti-neoplastic activity. Potent inhibitor of RNA polymerase.1 Induces apoptosis in a variety of cancer cell...

  • Focus Biomolecules cell signaling supplier, chemical structure of Afatinib | EGFR, HER2 inhibitor | CAS 850140-72-6
    $85.00
    Afatinib (850140-72-6) is a clinically useful kinase inhibitor approved for the treatment of non-small cell lung cancer. It is a potent and highly selective inhibitor of mutant and wild-type EGFR (IC50= 0.5 nM) and HER2...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Amifostine | Cellular protectant | CAS 20537-88-6
    $56.00
    Amifostine (20537-88-6) is a broad sprectrun radio- and chemoprotective agent.1 Prevents chemotherapy-induced apoptosis, upregulates HIF-1α and restores transcriptional activity in specific p53 mutants.2-4...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Ansatrienin B | Cytotoxic activity | CAS 82189-04-6
    $345.00
    Ansatrienin b (82189-04-6) represents a novel class of ansamycins.1 Inhibits osteoclastic bone resorption.2 Potentiates the activity of several clinically useful antitumor agents.3 Translation inhibitor which prevents ICAM-1...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Axitinib | VEGFR kinase inhibitor | CAS 319460-85-0
    $40.00
    Potent inhibitor of VEGFR-2, -3, and -1, IC50 = 0.2, 0.1-0.3, and 1.2 nM respectively1 displaying minimal activity against a panel of ~100 protein kinases. Inhibits angiogenesis and vascular permeability.2 Also inhibits...

  • Focus Biomolecules supplier, chemical structure of Bexarotene | Retinoid RXR agonist | CAS 153559-49-0
    $40.00
    Bexarotene (153559-49-0) is a highly potent and selective retinoid X receptor (RXR) agonist (EC50=28, 25, 20 nM for RXRα, β, γ respectively).1 Clinically useful antineoplastic agent for cutaneous T-cell...

  • Binimetinib | MEK1/2 inhibitor
    $39.00
    Binimetinib (606143-89-9) is a potent (IC50 = 12 nM) and selective allosteric inhibitor of MEK1/2.1,2 Recently approved by the FDA for treatment of melanoma in combination with Encorafenib. Binimetinib has had limited...

  • Focus Biomolecules supplier, chemical structure of Bleomycin sulfate | Induces double strand DNA breaks | CAS 9041-93-4
    $90.00
    Bleomycin sulfate (9041-93-4) coordinates with metals producing reactive oxygen species which causes oxidative damage to DNA1 and RNA2. Induces double-strand DNA damage.3 Commonly used to induce lung fibrosis in animal...

  • Focus Biomolecules supplier, chemical structure of Bortezomib | Proteasome inhibitor | CAS 179324-69-7
    $50.00
    Potent and selective proteasome inhibitor (Ki=0.6 nM). Inhibits proliferation of a number of tumor cell lines (IC50=7 nM).  Inhibits TNFα synthesis and FGF-induced angiogenesis. Clinically useful agent for...

  • Focus Biomolecules cell signaling supplier, chemical structure of Cabozantinib | MET & VEGFR2 inhibitor | CAS 849217-68-1
    $70.00
    Cabozantinib (849217-68-1) is a novel inhibitor of c-met and VEGFR2 kinase activity, IC50=3.5 nm and 35 pM respectively.1 Inhibits MET-activating kinase domain mutations Y1248H, D1246N or K1262R, IC50=3.8, 11.8 and 14.6 nM...

  • Focus Biomolecules supplier, chemical structure of Carfilzomib | Proteasome inhibitor | CAS 868540-17-4
    $50.00
    Carfilzomib (868540-17-4) is a potent and irreversible proteasome inhibitor.1 Synthetic analog of the microbial product epoxomcin.2 Compared to bortezomib it displays equal potency but greater selectivity for the...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Cisplatin | Anticancer agent | CAS 15663-27-1
    $50.00
    Induces intra- and interstrand DNA adducts which poison topoisomerase I.1 Synergizes with topoisomerase I inhibitors such as topotecan.1 Induces apoptosis by sequential activation of caspase-8, -3 and -6 in osteosarcoma...

  • Focus Biomolecules cell signaling supplier, chemical structure of Crizotinib | c-MET and ALK inhibitor | CAS 877399-52-5
    $80.00
    Crizotinib (877399-52-5) is a potent and selective inhibitor of c-MET and ALK, IC50's=8 and 20 nM respectively.1 Inhibition of cell proliferation was associated with G1-S phase cell cycle arrest and induction of...

  • Focus Biomolecules cell signaling supplier, chemical structure of Dabrafenib | B-Raf mutant inhibitor | CAS 1195765-45-7
    $34.00
    Dabrafenib (1195765-45-7) is a selective inhibitor of mutant B-RafV600E (IC50 = 0.8 nM), with 4- and 6-fold reduced potency against wild type B-Raf and c-Raf (IC50 = 3.2 and 5 nM, respectively).1 Has been in clinical...

  • Focus Biomolecules supplier, chemical structure of Dasatinib | Src and Bcr/Abl inhibitor | CAS 302962-49-8
    $50.00
    Dasatinib (302962-49-8) inhibits Src, Bcl/Abl and Lyn tyrosine kinases (IC50= 0.55, 3.0 and 8.5 nM respectively).1,2 Suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell...

  • Daunorubicin HCl | DNA Damaging Agent / Anticancer Agent
    $60.00
    Antitumor antibiotic used in the treatment of acute myeloid leukemias.1 Induces DNA damage by intercalation.2 Induces apoptosis in a variety of cell lines.3 Inhibition of autophagy with chloroquine enhances...

  • Focus Biomolecules cell signaling tech supplier, chemical structure Decitabine | DNA hypomethylation agent | CAS 2353-33-5
    $60.00
    Decitabine (2353-33-5) inhibits DNA methyltransferase. Induces demethylation and reactivation of silenced genes. Increases stem cell reprogramming efficiency. Decitabine stimulates osteogenic differentiation of human bone...

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