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Chemotherapeutics

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  • Focus Biomolecules supplier, chemical structure of Dasatinib | Src and Bcr/Abl inhibitor | CAS 302962-49-8
    $50.00
    Dasatinib (302962-49-8) inhibits Src, Bcl/Abl and Lyn tyrosine kinases (IC50= 0.55, 3.0 and 8.5 nM respectively).1,2 Suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell...

  • Daunorubicin HCl | DNA Damaging Agent / Anticancer Agent
    $60.00
    Antitumor antibiotic used in the treatment of acute myeloid leukemias.1 Induces DNA damage by intercalation.2 Induces apoptosis in a variety of cell lines.3 Inhibition of autophagy with chloroquine enhances...

  • Focus Biomolecules cell signaling tech supplier, chemical structure Decitabine | DNA hypomethylation agent | CAS 2353-33-5
    $60.00
    Decitabine (2353-33-5) inhibits DNA methyltransferase. Induces demethylation and reactivation of silenced genes. Increases stem cell reprogramming efficiency. Decitabine stimulates osteogenic differentiation of human bone...

  • Focus Biomolecules supplier, chemical structure of Docetaxel | Microtubule stabilizing agent | CAS 114977-28-5
    $35.00
    Docetaxel (114977-28-5) is an antimitotic chemotherapeutic which inhibits via reversible high-affinity binding to microtubules1. Induces apoptosis in a variety of cancer cell lines2 however, tumor cells can quickly develop...

  • Focus Biomolecules supplier, chemical structure of Doxorubicin HCl | DNA damaging agent | CAS 25316-40-9
    $45.00
    Doxorubicin HCl (25316-40-9) is an antitumor antibiotic. Induces DNA damage by intercalation1 and inhibition of topoisomerase II. Doxorubicin HCl induces apoptosis in a variety of cell lines2. Acts as a substrate for MDR13...

  • Duvelisib | PI3Kdelta/gamma inhibitor
    $65.00
    Duvelisib (1201438-56-3) is a potent and selective (IC50’s: PI3Kα = 1602nM, PI3Kβ = 85nM, PI3Kδ= 2.5nM, PI3Kγ = 27nM) dual PI3Kδ/γ inhibitor.1 It inhibits B and T cell proliferation,...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Enasidenib | Inhibitor of IDH2 | CAS 1446502-11-9
    $55.00
    Enasidenib (1446502-114-9) is a potent (IC50’s = 100 nM IDH2R140Q homodimer, 30 nM IDH2R140Q/WT heterodimer and 10 nM IDH2R172K/WT heterodimer) and selective inhibitor of mutant isocitrate dehydrogenase 2 (IDH2)...

  • Focus Biomolecules supplier, chemical structure of Eniluracil | Dihydropyrimidine dehydrogenase inhibitor | CAS 59989-18-3
    $40.00
    Eniluracil (59989-18-3) is an irreversible dihydropyrimidine dehydrogenase (DPD) inhibitor.1,2,3  DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU). ...

  • Enzalutamide | Antiandrogen
    $50.00
    Enzalutamide is a clinically useful non-steroidal antiandrogen (IC50 = 36 nM) for the treatment of castration-resistant prostate cancer.1,2 It impairs binding of the androgen receptor to DNA, the recruitment of...

  • Focus Biomolecules cell signaling supplier, chemical structure of Epirubicin HCl | DNA damaging agent | CAS 56390-09-1
    $48.00
    Epirubicin HCl (56390-09-1) is an antitumor agent.1 Inhibits topoisomerase II.2 Induces DNA damage by a number of different mechanisms including intercalation, free radical-mediated oxidation, crosslinking,...

  • Focus Biomolecules supplier, chemical structure of Erlotinib HCl | EGFR Kinase inhibitor | CAS 183319-69-9
    $35.00
    Erlotinib HCl (182219-93-9) is a potent inhibitor of EGFR tyrosine kinase (IC50 = 2 nM).1 Potent inhibitor of mutant JAK2-V617F.2 Weaker inhibitor of ErbB-2 kinase (Ki = 1 μM) ErbB-4 kinase (Ki = 1.5 μM).3 HDAC...

  • Focus Biomolecules cell signaling reagent supplier, structure of Etoposide | Topoisomerase II inhibitor | CAS 33419-42-0
    $45.00
    Etoposide (33419-42-0) is a chemotherapeutic agent that forms a ternary complex with DNA and topoisomerase II, preventing re-ligation of DNA strands causing DNA cleavage. Etoposide blocks the cell cycle in S-phase and...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Everolimus | mTOR inhibitor | CAS 159351-69-6
    $50.00
    Everolimus (159351-69-6) is a semisynthetic analog of rapamycin (Cat.# 10-1104) with potent immunosuppressive activity.1 Inhibits mTOR.2 Everolimus is a clinically useful immunosuppressant.3 References/Citations1)...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Fludarabine | DNA synthesis inhibitor | CAS 950455-15-9
    $40.00
    Fludarabine (21679-14-1) is a synthetic adenosine analog that inhibits DNA biosynthesis and is a clinically useful antineoplastic agent.1 In cells fludarabine accumulates as its 5’-triphosphate (F-ara-ATP) for which...

  • Focus Biomolecules cell signaling reagent supplier, structure of Gefitinib | EGFR kinase inhibitor | CAS 184475-35-2
    $30.00
    Gefitinib (184475-35-2) is a potent and selective EGFR kinase inhibitor (IC50 = 23-79 nM)1. Inhibits EGFR autophosphorylation and inhibits tumor growth in vivo2. Enhances efficacy of cytotoxic agents3. Inhibits growth factor...

  • Focus Biomolecules supplier, chemical structure of Gemcitabine HCl | DNA polymerase inhibitor | CAS 122111-03-9
    $30.00
    Gemcitabine HCl (122111-03-9) is a clinically useful anticancer agent.1 It exerts its cytotoxic effects via the metabolites gemcitabine diphosphate (dFdCDP) and gemcitabine triphosphate (dFdCTP). dFdCTP is an inhibitor of...

  • Focus Biomolecules supplier, chemical structure of Gimeracil | Dihydropyrimidine dehydrogenase inhibitor | CAS 103766-25-2
    $50.00
    Gimeracil (103766-25-2) is a dihydropyrimidine dehydrogenase (DPD) inhibitor.  DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU).  Gimeracil is used along...

  • Ibrutinib | BTK inhibitor
    $40.00
    Ibrutinib (936563-96-1) is a very potent (IC50 = 0.5nM) irreversible inhibitor of Bruton tyrosine kinase (BTK) that blocks activation of the B-cell antigen receptor (BCR).1 Ibrutinib also potently inhibits several other...

  • Imiquimod | TLR7 Agonist
    $30.00
    Imiquimod (99011-02-6) is a Toll-like receptor 7/8 agonist with anti-viral and anti-tumor properties.1 Enhances innate immune system leading to Th1-mediated antitumor immune response.2 Increases levels of IFNα,...

  • Focus Biomolecules supplier, chemical structure of Irinotecan HCl | Topoisomerase I inhibitor | CAS 136572-09-3
    $60.00
    Irinotecan (136572-09-3) is a semi-synthetic derivative of camptothecin (Cat.# 10-1041) that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38,...