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Chemotherapeutics

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  • Focus Biomolecules cell signaling supplier, chemical structure of Lapatinib (base) | EGFR & HER2 inhibitor | CAS 231277-92-2
    $50.00
    Lapatinib (231277-92-2) is a potent inhibitor of EGFR kinase (Ki=3 nM), Erb-2 kinase (Ki=13 nM) Erb-4 kinase (Ki=347 nM).1  Clinically useful agent for treatment of breast cancer.2-3 Cell...

  • Larotrectinib | Potent and selective panTRK inhibitor
    $65.00
    Larotrectinib (1223403-58-4) is a potent (IC50’s < 11 nM) inhibitor of tropomyosin receptor kinases A, B, and C (TrkA, B, and C).1 It is >100 fold selective against a panel of 229 kinases. Larotrectinib markedly...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Lenalidomide | Immunomodulator | CAS 191732-72-6
    $35.00
    Lenalidomide (191732-72-6) is a thalidomide analog which, like thalidomide1, binds to cereblon which is the substrate recognition component of a cullin-dependent ubiquitin ligase and inhibits its autoubiquitination activity2...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Lenvatinib | VEGFR inhibitor | CAS 417716-92-8
    $55.00
    Lenvatinib (417716-92-8) is a potent inhibitor of VEGFR2 and R3, IC50s=4.0 and 5.2 nM respectively.1  Also inhibits VEGFR1, FGFR1, PDGFR3b and Kit, IC50s=22, 46, 39 and 100 nM respectively.1 Suppresses lymph node and...

  • Methotrexate | Dihydrofolate reductase inhibitor
    $50.00
    Methotrexate (133073-73-1) is a synthetic folic acid analog with immunosuppressant and cancer chemotherapeutic activity.1 Inhibits thymidylate synthetase and de novo purine synthesis.2,3 Displays beneficial effects in...

  • Focus Biomolecules cell signaling tech supplier, structure of Mitomycin C | DNA crosslinking & damaging agent | CAS 50-07-7
    $45.00
    Mitomycin C (50-07-7) is a DNA damaging and crosslinking agent. Induces apoptosis in various cell lines. Cell permeable. This product is not approved for human therapeutic use. References/Citations1) Tee and Proud (2000),...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Nilotinib | BCR-ABL inhibitor | CAS 641571-10-0
    $30.00
    Nilotinib (CAS 641571-10-0) is a novel, selective BCR-ABL inhibitor.  More potent than imatinib against wild-type BCR-ABL (IC50 < 30 nM).1 Induces apoptosis.2 References/Citations 1) Weisberg et al...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Olaparib | PARP1 inhibitor | CAS 763113-22-0
    $40.00
    Olaparib (763113-22-0) is a highly potent and selective PARP-inhibitor with IC50 values of 5 nM and 1 nM for PARP-1 and PARP-2, respectively.1  In a genetically engineered mouse model for BRCA1-associated breast cancer...

  • Pemetrexed 2Na | Multitargeted antifolate
    $40.00
    Pemetrexed (357166-29-1) is a multi-targeted antifolate with antitumor activity. It potently inhibits folate-dependent enzymes involved in both purine and pyrimidine synthesis including thymidylate synthase (Ki = 109 nM),...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Rapamycin | mTOR inhibitor | CAS 53123-88-9
    $48.00
    Rapamycin (53123-88-9) is a clinically useful immunosuppressant. Inhibits the response to interleukin-2 blocking activation of T- and B-cells.1 Rapamycin forms a complex with cytosolic FK-binding protein 12 (FKB12) that...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Ribociclib | CDK4/6 inhibitor | CAS 1211441-98-3
    $70.00
    Ribociclib (1211441-98-3) is a clinically useful, potent, and specific CDK4/6 inhibitor.1,2,3  It was recently approved for use in HR+, HER2- metastatic breast cancer. References/Citations 1) Rader et al. (2013), Dual...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Romidepsin | HDAC inhibitor | CAS 128517-07-7
    $50.00
    Romidepsin (128517-07-7) is a potent and selective inhibitor of class I histone deacetylases (HDACs), IC50 = 36, 47, 510 and 14,000 nM for HDAC1, 2, 4 and HDAC6, respectively.1 Induces apoptosis in a variety of cell...

  • Rucaparib phosphate | PARP1 inhibitor
    $70.00
    Rucaparib phosphate (459868-92-9) is a potent (Ki<5 nM) PARP1 inhibitor.1 Cytotoxic to human cancer cells or xenograft tumors with mutated or epigenetically silenced BRCA1/2.2 Demonstrates antiproliferative effects in 26...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Ruxolitinib | JAK inhibitor | CAS 941678-49-5
    $70.00
    Potent and selective JAK1&2 inhibitor, IC50s=2.7, 4.5 and 322 nM forJAK1, JAK2 and JAK3 respectively.1  Blocks IL-6 signaling (IC50=281 nM) and proliferation of JAK2V617F+ Ba/F3 cells (IC50=127 nM).2 Inhibits the...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of SAHA | HDAC inhibitor | CAS 149647-78-9
    $35.00
    SAHA (149647-78-9) is a potent and selective histone deacetylase inhibitor. Induces apoptosis in a variety of tumor cell lines. SAHA synergizes with kinase inhibitors to kill CNS tumor cells. Cell permeable...

  • Focus Biomolecules cell signaling tech supplier, chemical structure SN-38 | DNA topoisomerase I inhibitor | CAS 86639-52-3
    $75.00
    SN-38 (86639-52-3) is the active metabolite of CPT-11 that inhibits DNA topoisomerase I (IC50 values are 0.74 and 1.9 μM in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC50 values are 0.077 and 1...

  • Focus Biomolecules supplier, chemical structure of Sorafenib | Inhibitor of Raf-1 and other kinases | CAS 475207-59-1
    $40.00
    Sorafenib (475207-59-1; base) was initially developed as a Raf kinase inhibitor, IC50 = 6 nM, but has been shown to inhibit many receptor tyrosine kinases including BRAF (IC50 = 22 nM); VEGFR-2 (IC50 = 90 nM); VEGFR-3 (IC50...

  • Focus Biomolecules cell signaling reagent supplier, Sunitinib malate | VEGFR, PDGFR kinase inhibitor | CAS 341031-54-7
    $50.00
    Sunitinib malate (341031-54-7) is a potent inhibitor of multiple receptor tyrosine kinases including VEGFR, PDGFRβ and Kit (Ki = 2-17 nM)1. Also inhibits cFMS (IC50=7 nM)2 and FLT33. Potent inhibitor of angiogenesis4...

  • Focus Biomolecules cell signaling tech supplier, structure Tamoxifen citrate | ER Antagonist; GPR30 agonist | CAS 54965-24-1
    $30.00
    Tamoxifen citrate (54965-24-1) is an estrogen receptor antagonist/partial agonist. Induces oxidative stress and apoptosis in estrogen receptor-negative cancer cell lines1. Displays neuroprotective effects in permanent focal...

  • Focus Biomolecules supplier, chemical structure of Taxol | Microtubule stabilizing agent | CAS 33069-62-4
    $25.00
    Taxol (33069-62-4) is a clinically useful cancer chemotherapeutic agent for the treatment of breast, non-small cell lung and ovarian cancer.1 Taxol acts as a promoter of tubulin polymerization and stabilizes microtubules in...