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Chemotherapeutics

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Temozolomide | Autophagy inducer | CAS 85622-93-1
    $75.00
    Temozolomide (85622-93-1) is a DNA alkylating agent with antitumor and antiangiogenic activity.1,2 Clinically useful anticancer agent.3 Temozolomide induces autophagy in a variety of cell lines.4 Cell...

  • Focus Biomolecules cell signaling reagent supplier, structure of Thalidomide | E3 UB ligase inhibitor | CAS 50-35-1
    $50.00
    Thalidomide (50-35-1) binds to the E3 ubiquitin ligase complex formed between CRBN, DDB1 and Cul4A, and inhibits the ligase activity. Inhibits TNF synthesis and FGF-induced angiogenesis. Cell permeable. Handle with caution,...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Trametinib | MEK inhibitor | CAS 871700-17-3
    $40.00
    Trametinib (871700-17-3) is a highly potent (IC50 uMEK1 = 0.7 nM, pp-MEK1 = 14.9 nM)1 and selective MEK inhibitor displaying selective inhibition of proliferation in various BRAF mutant cancer cell lines (IC50 ACHN = 9.8 nM;...

  • Focus Biomolecules reagent supplier, chemical structure of Trifluorothymidine | Thymidylate synthase inhibitor | CAS 70-00-8
    $45.00
    Trifluorothymidine (70-00-8) is an analog of thymidine which inhibits thymidylate synthase possesses antiviral and anticancer activity.1,2  After phosphorylation by thymidine kinase, it is incorporated into DNA where it...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Vandetanib | VEGFRK inhibitor | CAS 443913-73-3
    $40.00
    Vandetanib (443913-73-3) is a potent and selective inhibitor of  VEGFR2, ( KDR IC50 = 40 nM). Also inhibits fms-like tyrosine kinase 4 (VEGFR3, IC50 = 110 nM) and epidermal growth factor receptor (EGFR/HER1, IC50 = 500...

  • Focus Biomolecules supplier, chemical structure of Vinblastine sulfate | Microtubule depolymerizer | CAS 143-67-9
    $48.00
    Vinblastine sulfate (143-67-9) is a semisynthetic alkaloidal anticancer agent. Induces cell cycle arrest at G2/M phase by inhibiting mitotic spindle formation.1 Inhibits normal microtubule assembly and induces aberrant...

  • Focus Biomolecules supplier, chemical structure of Vincristine sulfate | Microtubule depolymerizer | CAS 2068-78-2
    $30.00
    Vincristine sulfate (2068-78-2) arrests cell cycle at G2/M by interfering with mitotic spindle formation. Depolymerizes microtubules and blocks binding of tubulin to microtubule proteins.1,2 Induces apoptosis...