DNA Damage
Showing 1–12 of 34 results
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New Products
(+)-Cedrol | Anticancer natural product
Cedrol is a sesquiterpene alcohol found in conifers mainly of the genera Cupressus, Juniperus, and Cedrus. It has been found to possess significant...$30.00 – $80.00 Select options -
Cancer
2′-Deoxy-5-fluorocytidine | Irreversible DNA methyl transferase inhibitor
2'-Deoxy-5-fluorocytidine (10356-76-0) is a DNA methyltransferase inhibitor currently in clinical trials for breast cancer and other solid tumors.1...$52.00 – $208.00 Select options -
Cancer
4-HQN | PARP inhibitor
4-HQN (491-36-1) is an inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50 = 9.5 μM).1 Displays mixed inhibition with respect to NAD+. Protective...$30.00 Select options -
Approved Drugs
6-Mercaptopurine | Purine antimetabolite and immunomodulator
6-Mercaptopurine (6112-76-1) ) is a purine antimetabolite drug used to treat acute lymphocytic leukemia, Crohn’s disease, ulcerative colitis, and i...$25.00 – $40.00 Select options -
Approved Drugs
6-Thioguanine | Anticancer agent / Downregulates DNMT1
6-Thioguanine (154-42-7) is a DNA methyltransferase inhibitor. After incorporation into DNA, it disrupts cytosine methylation by DNA methyltransfe...$30.00 – $110.00 Select options -
Cancer
8-Oxo-2′-deoxyguanosine | Marker for DNA damage
8-Oxo-2'-deoxyguanosine (88847-89-6) is a useful marker for DNA damage via a variety of oxidative processes.1 It is a critical biomarker for oxidat...$38.00 – $160.00 Select options -
New Products
Adavosertib | Wee1 kinase inhibitor
Adavosertib (955365-80-7) inhibits Wee1 tyrosine kinase (IC50 = 5.2 nM) thus preventing phosphorylation of CDC2 and abrogating the G2 DNA damage ch...$45.00 – $155.00 Select options -
Bioinorganic chemistry
Bleomycin sulfate | Induces double strand DNA breaks
Bleomycin sulfate (9041-93-4) coordinates with metals producing reactive oxygen species which causes oxidative damage to DNA1 and RNA2. Induces dou...$75.00 – $250.00 Select options -
New Products
CBL0137 | Inhibitor of the histone chaperone FACT
CBL0137 (1197996-80-7) is an anticancer agent that activates p53 and suppresses NF-kB via trapping of the FACT (facilitates chromatin transcription...$80.00 – $295.00 Select options -
Apoptosis
Cisplatin | Anticancer agent
Cisplatin (15663-27-1) induces intra- and interstrand DNA adducts which poison topoisomerase I.1 Synergizes with topoisomerase I inhibitors such as...$50.00 – $200.00 Select options -
Antivirals
Cytarabine | Anticancer agent
Cytarabine (147-94-4) is a nucleoside analog that interferes with DNA synthesis and transcription, particularly in tumor cells.1,2 Cellular enzymes...$40.00 – $90.00 Select options -
Apoptosis
Daunorubicin HCl | DNA Damaging Agent / Anticancer Agent
Daunorubicin HCl (23541-50-6) is an antitumor antibiotic used in the treatment of acute myeloid leukemias.1 Induces DNA damage by intercalation.2 I...$60.00 – $190.00 Select options
