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Drug Resistance

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  • Ko-143 | 461054-93-3 | Structure | Supplier
    A potent and selective inhibitor of the breast cancer resistance protein multidrug transporter (BCRP/ABCG2)1. Reverses resistance of MTX and topotecan at 25 nM in human and mouse cell lines.1 Also inhibits ABCB1 and ABCC1 at...

  • MK-571 | 115104-28-4 | Structure | Supplier
    MK-571 (115104-28-4) is a potent (EC50 = 1.3nM) and selective Leukotriene D4 antagonist (LTD4)1 displaying inverse agonist activity2. Blocks binding of LTD4 to human (Ki = 0.22 nM) and guinea pig (Ki = 2.1 nM) lung membranes...

  • Napabucasin | STAT3 inhibitor / Cancer cell stemness inhibitor
    Napabucasin (83280-65-3) inhibits gene transcription driven by STAT3. Inhibits cancer cell stemness gene expression and blocks spherogenesis of stemness-high cancer cells isolated from a variety of cancer types.1 Effective...

  • NGI-1 | Oligosaccharyltransferase (OST) inhibitor
    NGI-1 (790702-57-7) is a cell-permeable inhibitor of oligosaccharyltransferase (OST) – IC50 = 1.1 µM.1 It blocks cell-surface localization and signaling of the epidermal growth factor receptor (EGFR) glycoprotein...

  • Nicardipine HCl | L-type Ca channel blocker / MDR inhibitor
    Nicardipine (54527-84-3) is a clinically useful L-type calcium blocker. Inhibitor of MDR.2 References/Citations1) Merck 14 6495 2) Hulubei et al. (2012), 4-Isoxazolyl-1,4-dihydropyridines exhibit binding at the...

  • Panobinostat | HDAC inhibitor
    Panobinostat (404950-80-7) is a potent inhibitor of class I and II HDACs.1 Cotreatment with panobinostat and an HSP90 inhibitor caused synergistic apoptosis in human CML-BC and AML cells.2 A potent antimyeloma...

  • S-Farnesyl-L-cysteine methyl ester | Multidrug resistance transporter activator
    S-Farnesyl-L-cysteine methyl ester (125741-64-2) stimulates multidrug resistance transporter ATPase activity (4-5 fold at 10-20 µM) and competes for drug binding.1 It modifies the carboxyl terminus of the Saccharomyces...

  • Salinomycin Na | Cancer stem cell inhibitor
    Salinomycin Na (55721-31-8) is a polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma...

  • SMED-1 | Structure | Supplier
    A dexamethasone (Dex) sensitizer. SMED-1 was discovered in a screen designed to identify compounds that sensitize Dex-resistant ALL xenografts to Dex.1 The assay employed Dex-resistant ALL-19 cells which are resistant at...

  • Verapamil HCl | 152-11-4 | Structure | Supplier
    Verapamil HCl (152-11-4) is a clinically useful L-type calcium channel blocker.1 It is also used as an inhibitor of drug efflux pump proteins.2 References/Citations1) Brgden and Benfield (1996) Verapamil: a review of its...

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