Epigenetics
Showing 1–12 of 48 results
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Cancer
2′-Deoxy-5-fluorocytidine | Irreversible DNA methyl transferase inhibitor
2'-Deoxy-5-fluorocytidine (10356-76-0) is a DNA methyltransferase inhibitor currently in clinical trials for breast cancer and other solid tumors.1...$50.00 – $120.00 Select options -
Cancer
Anacardic Acid | HAT inhibitor
Anacardic acid (16611-84-0) is a natural product found in cashew nut oil. It is an inhibitor of the histone acetyltransferases p300 and PCAF (IC50...$35.00 – $140.00 Select options -
New Products
BG45 | HDAC3 selective inhibitor
BG45 (926259-99-6) is a potent and selective HDAC3 inhibitor (IC50 = 289 nM), IC50s for HDAC1, 2 and 6 = 2, 2.2 and >20 mM respectively.1 Inhibi...$60.00 – $240.00 Select options -
New Products
BI 2536 | Dual Plk/BRD4 inhibitor – Destabilizes Myc
BI 2536 (755038-02-9) was originally reported as a potent (IC50’s Plk1 = 0.83nM, Plk2 = 3.5nM and Plk3 = 9.0nM)1 and selective2 Polo-like kinase in...$75.00 – $275.00 Select options -
New Products
BI-9564 | BRD9 bromodomain inhibitor
BI-9564 (1883429-22-8) is a potent, selective, and cell permeable inhibitor of the BRD9 bromodomain, a subunit of the switch/sucrose nonfermentable...$60.00 – $195.00 Select options -
New Products
BZ1 | BPTF inhibitor
BZ1 (2766623-38-3) is a potent (Kd = 6.3 nM; IC50 = 67 nM BPTF Alphascreen) inhibitor of the bromodomain PHD finger transcription factor (BPTF). I...$65.00 – $250.00 Select options -
Cancer
C-646 | HAT inhibitor
C-646 (328968-36-1) is a potent and selective inhibitor of the histone acetyl transferase p300/CBP (Ki=400 nM ). Induces apoptosis in prostate canc...$80.00 – $320.00 Select options -
New Products
C-DIM 8 | Nur77 Antagonist
C-DIM 8 (151358-47-3) is an antagonist of the orphan nuclear receptor Nur77 (NR4A1, TR3).1 Induces reactive oxygen species and ER stress in pancrea...$40.00 – $150.00 Select options -
Apoptosis
CI-994 | HDAC Inhibitor
CI-994 (112522-64-2) is an orally active histone deacetylase (HDAC) inhibitor, IC50 = 0.9, 0.9, 1.2 and >20 μM for HDAC1, HDAC2, HDAC3 and HDAC8...$38.00 – $150.00 Select options -
New Products
CPI203 | BET bromodomain inhibitor
CPI203 (1446144-04-2), a JQ1 analog, is a potent and selective inhibitor of the BET bromodomain BRD4 (IC50 = 26 nM).1 It helps promote the maintena...$100.00 – $350.00 Select options -
Cancer
CUDC-101 | Dual HDAC and EGFR inhibitor
CUDC-101 (1012054-59-9) is a novel hybrid dual-acting HDAC and receptor tyrosine kinase inhibitor. It is a potent HDAC inhibitor which also inhibit...$70.00 – $280.00 Select options -
New Products
DBIC | DNMT3B S-nitrosylation inhibitor
DBIC (487026-67-5) specifically inhibits S-nitrosylation of DNA methyltransferase 3B (DNMT3B) at low concentrations, IC50≤100 nM, without affecting...$75.00 – $300.00 Select options
