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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Sirtinol | SIRT inhibitor | CAS 410536-97-9
    Sirtinol (410536-97-9) is an inhibitor of sirtuin family enzymes including human SIRT1 (IC50=60 μM), human SIRT2 (IC50=58 μM), and yeast Sir2 (IC50=48 μM) with no inhibition of human HDAC1. Active in vivo and in...

  • SP2509 | LSD1 inhibitor
    SP2509 (1423715-09-6) is a potent (IC50 = 13 nM) and reversible inhibitor of the histone demethylase LSD1 (KDM1A).1 It is inactive against the closely related flavin enzymes MAO A,B as well as lactate dehydrogenase, several...

  • Focus Biomolecules supplier, structure of TC-E 5033 | Arginine methyltransferase 1 (PRMT1) inhibitor | CAS 17328-16-4
    TC-E 5003 (17328-16-4) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor, IC50 = 1.5 μM. Displays no activity against CARM1 and Set7/9 methyltransferases. TC-E 5003 inhibits growth of MCF7a breast...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Trichostatin A | HDAC inhibitor | CAS 58880-19-6
    Trichostatin A (58880-19-6) is a potent and selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). Induces reversion of ras transformed cells to normal morphology. Trichostatin A induces dedifferentiation of...

  • Focus Biomolecules cell signaling supplier, chemical structure UNC0379 | Selective SETD8 inhibitor | CAS 1620401-82-2
    UNC0379 (CAS 1620401-82-2) is an inhibitor of the lysine methyltransferase SETD8 with selectivity over 15 other methyltransferases.1 IC50’s = 7.3 µM in a radioactive methyl transfer assay and 9.0 µM in an...

  • Focus Biomolecules cell signaling supplier, chemical structure of UNC1999 | Methyltransferase inhibitor | CAS 1431612-23-5
    UNC1999 (1431612-23-5) is an orally bioavailable, highly selective inhibitor of both wild-type and mutant EZH1 and EZH2 lysine methyltransferases (IC50's = 45 nM and 2 nM respectively).1 Inhibition of EZH2 with UNC1999...

  • Focus Biomolecules cell signaling tech supplier, chemical structure Zebularine | DNA methylation inhibitor | CAS 3690-10-6
    Zebularine (3690-10-6) is an orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC50 = 120 μM) and re-activates silenced genes in T24 bladder carcinoma cells. Zebularine inhibits cytidine...

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