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  • C-DIM 12 | Nurr1 activator; NFkB inhibitor
    C-DIM 12 (178946-89-9) activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth.1,2 Nurr1 is a suppressor of NFkB-related neuroinflammatory genes in microglia and astrocytes and C-DIM 12 suppresses...

  • DiMNF | 14756-24-2 | Structure | Supplier
    DiMNF (14756-24-2) is a selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). It exhibits antiinflammatory activity including suppression of cytokine-mediated acute phase genes through dissociation of...

  • FPS-ZM1 | RAGE receptor antagonist
    FPS-ZM1 (945714-67-0) is a high-affinity RAGE (Receptor for Advanced Glycation End products) receptor antagonist (IC50 = 0.6 μM). It lowers levels of Aβ via binding to the V domain of RAGE and can block multiple...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Sulindac Sulfide | NFkB inhibitor | CAS 32004-67-4
    Sulindac sulfide (32004-67-4) is the active metabolite of cyclooxygenase inhibitor sulindac.1 Strongly inhibits Ras induced malignant transformation and Ras/Raf dependent transactivation.2 Sulindac sulfide induces apoptosis...

  • TG 4-155 | 1164462-05-8 |Structure | Supplier
    TG 4-155 (1164462-05-8) is a potent and selective prostaglandin EP2 receptor antagonist, KB = 2.4 and 34.5 nM for EP2 and DP1 receptors respectively. Displays >500-fold selectivity for EP2 over other prostanoid receptors...

  • Focus Biomolecules cell signaling reagent supplier, structure of Xanthohumol | VCP / Autophagy inhibitor | CAS 6754-58-1
    Xanthohumol (6754-58-1) binds to the N-terminal domain of valosin-containing protein (VCP), an essential protein for autophagosome maturation. Xanthohumol inhibits the function of VCP thereby impairing autophagosome...

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